A Microwave System for Medicinal Chemistry and Radiochemistry Research

侯博士、坎贝尔博士和蒋博士的研究项目一直在通过将有机合成、放射化学、药物化学、计算化学和生物化学结合起来来寻找新的诊断和治疗工具。成功发现新的治疗工具和诊断工具将大大改善疾病的预防、早期诊断和管理。如果疾病能更早发现、更早治疗和更有效监测，许多人的生活质量将得到改善。这将提高保健质量，减轻保健系统的负担。侯博士的研究重点是氟-18标记的分子成像剂的发现，用于使用正电子发射断层扫描（PET）进行癌症成像的潜在用途，以及放射性成像方法的开发。坎贝尔博士的研究小组专注于开发放射化学的新合成程序，并将其应用于新成像剂的开发。姜博士的研究涉及合成用于靶向癌症治疗的肽和碳水化合物。本申请中所要求的微波反应器系统是一种多功能合成器，其可以进行快速微波辅助有机合成，并且是整个学术化学研究实验室和制药工业中使用的标准设备。与使用油浴和热板的传统回流加热相比，它提供了几个优点，包括提高的产率，更短的反应时间，从几天或几小时到几分钟，并有助于进入新的化学空间。它已成为合成有机化学、药物化学和放射化学的重要工具，也是侯博士、坎贝尔博士和江博士在开发治疗和诊断分子工具方面的研究计划的关键要素。由所要求的设备支持的研究方案将在许多方面使加拿大受益。首先，这项研究将导致发现用于预防、早期诊断和疾病管理的成像探针。其次，放射性转化和成像示踪剂的新方法的发明将提高加拿大（放射性）制药业的竞争力。最后，参与拟议研究计划的学生将接受最先进的微波辅助合成的深入培训，并将获得药物/成像剂合成和发现的全面知识和实践技能。这些设备，沿着研究项目，将允许培训下一代科学家，以更好地为在学术界或制药行业取得成功的职业生涯做好准备。

The research programs of Drs. Hou, Campbell and Jiang have been searching for novel diagnostic and therapeutic tools by bringing together organic synthesis, radiochemistry, medicinal chemistry, computational chemistry and biochemistry. Successful discovery of novel therapeutic tools and diagnostic tools will significantly improve prevention, early diagnosis and management of diseases. The quality of life of many people will be improved if diseases are detected earlier, treated sooner, and monitored more effectively. It will lead to improved quality of health care and a reduced burden on the health care system. Dr. Hou's research focuses on the discovery of Fluorine-18 labelled molecular imaging agents for potential use in the imaging of cancer using Positron Emission Tomography (PET), and the development of radio-fluorination methods. Dr. Campbell's research group is focused on the development of new synthetic procedures for radiochemistry and applying them to the development of new imaging agents. Dr. Jiang's research involves the synthesis of compounds derived from peptides and carbohydrates for targeted cancer therapy. The microwave reactor system requested in this application is a versatile synthesizer that can perform rapid microwave assisted organic synthesis, and is a standard piece of equipment used throughout academic chemistry research labs and in the pharmaceutical industries. It offers several advantages including improved yield, shorter reaction times from days or hours down to minutes, and facilitates access to new chemical space as compared to conventional reflux heating using oil baths and hot plates. It has become an essential tool in synthetic organic chemistry, medicinal chemistry and radiochemistry and a key element in the research programs of Drs. Hou, Campbell and Jiang in the development of therapeutic and diagnostic molecular tools. The research programs supported by the requested equipment will benefit Canada in many ways. Firstly, the research would lead to the discovery of imaging probes for prevention, early diagnosis and management of diseases. Secondly, the invention of novel methods for radio-transformations and imaging tracers will enhance the competitivity of Canadian (radio)pharmaceutical industry. Lastly, the students who are involved in the proposed research programs will receive in-depth training on the most advanced microwave-assisted synthesis and will gain comprehensive knowledge and hands-on skills for drug/imaging agent synthesis and discovery. The equipment, along with the research programs, will allow for the training of next generation scientists to better prepare for a successful career in academia or pharmaceutical industry.