Functional Rna And Cellular Stress

细胞必须适应不断变化的环境条件才能生存。有趣的是，一类新兴的生物分子(非编码RNA)最近被证明对许多这些反应途径是必不可少的。奥达斯博士的实验室将研究非编码RNA在应激诱导蛋白质转化为一种新型天然蛋白质聚集体中的作用。他打算确定与这一途径相关的调节因子、蛋白质靶标和细胞后果，从而增强我们对细胞适应性的理解。研究成果还将影响基于集合的神经疾病的研究，为抗击影响加拿大S老龄化人口的疾病创造新的途径。

Cells must adapt to changing environmental conditions in order to survive. Interestingly, an emerging class of biological molecules (noncoding RNA) have recently been shown to be essential to many of these responsive pathways. Dr. Audas¿ laboratory will study the role of noncoding RNA in the stress-induced conversion of proteins to a new type of natural protein aggregate. He intends to identify regulators, protein targets, and cellular consequences associated with this pathway, enhancing our understanding of cellular adaptability. Research outcomes will also impact the study of aggregate-based neurological diseases, generating new avenues to combat conditions affecting Canada¿s aging population.