Impact of natural biologics on the stress response: relationship between fear and appetitive brain circuits

具体目标：虽然压力源和其他高度突出的刺激会引起广泛的激素神经递质和行为反应，但潜在的触发机制仍不清楚。越来越多的注意力集中在几个肽能系统的作用上，在这些行为和生理反应的调解中，以及在寻求能够减轻这些反应的生物制剂方面。为了与我们的长期研究计划保持一致，拟议的研究将解决以下争议，最初集中在压力源上，然后是其他生物学上显著的事件：BBs和CRF作为中枢神经系统的调节因子，具有协调机体神经内分泌和对应激源的行为反应的综合特性。2. 压力源暴露会以不同的方式影响动机和/或情绪状态，这取决于所使用的压力源的类型。3. 系统性挑战（或应激源，如细菌内毒素，LPS）会引起行为和神经化学改变，使人想起那些由心因性应激源引起的改变。4. 暴露于食欲刺激会激活一些与那些被厌恶刺激激活的相同的肽回路。5. 这些厌恶或食欲事件的影响将被特定的植物来源的生物制剂所减弱，包括来自新热带藤蔓Souroubea Symptata Gilgi的活性成分，以及大麻植物提取物（THC， CBD和/或萜烯），通过它们对BBs和CRF系统的作用。

Specific objectives: While stressors and other highly salient stimuli provoke a wide range of hormonal neurotransmitter and behavioral responses, the underlying triggering mechanisms remain unclear. Increased attention is being focused on the role of several peptidergic systems, in the mediation of these behavioral and physiological responses and in the quest for biologics capable of mitigating those responses. In keeping with our long-term research program, the proposed studies will address the following contentions, initially focused on stressors and then to other biologically salient events: 1. BBs and CRF serve as CNS regulators with integrative properties coordinating the organism's neuroendocrine and behavioral responses to stressors. 2. Stressor exposure will impact motivational and/or emotional states in a variable fashion depending on the type of stressor employed. 3. A systemic challenge (or stressor, e.g. bacterial endotoxin, LPS) will provoke behavioral and neurochemical alterations reminiscent of those elicited by psychogenic stressors. 4. Exposure to an appetitive stimulus will activate some of the same peptidegic circuits as those activated by a aversive stimuli. 5. The effects of these aversive or appetitive events will be attenuated by specific plant-derived biologics, including active ingredients from the neotropical vine Souroubea Symptata Gilgi, and marijuana plant extracts (THC, CBD and/or the terpenes), through their action(s) on BBs and CRF system(s).