Towards a better understanding of the effect of the pentafluorosulfanyl group on the lipophilicity and acid/base properties of alcohols and amines

本项目旨在更好地了解五氟磺胺基对醇类和胺类的亲脂性和酸碱性质的影响。在这次国际合作中，加拿大拉瓦尔大学的jean - franois Paquin教授提议与比利时根特大学的Bruno linau教授合作，共同解决这一问题。Paquin教授的研究小组专注于合成有机氟化学，在含sf5化合物的合成方面具有特殊的专业知识，而Linclau教授的研究重点是研究有机化合物的氟化如何改变其物理性质，重点是氢键、亲脂性和构象。这一合作将两个在各自领域备受推崇的研究小组聚集在一起，共同开展一个项目，可能会在药物发现方面产生非常有影响力的发现。

This project aims to gain a better understanding of the effect of the pentafluorosulfanyl group on the lipophilicity and acid/base properties of alcohols and amines. In this international collaboration, Prof. Jean-François Paquin from Université Laval (Canada) propose to team up with Prof. Bruno Linclau from Ghent University (Belgium) to tackle this endeavour. Prof. Paquin's research group focuses on synthetic organofluorine chemistry with a particular expertise in the synthesis of SF5-containing compounds while Prof. Linclau's research is focused on investigating how fluorination of organic compounds can modify their physical properties, with a focus on hydrogen bonding, lipophilicity, and conformation. This collaboration brings together two highly regarded research groups in their respective field to work on a project that could lead to very impactful discoveries in drug discovery.