Point-of-care impedance-based technology to diagnose important infectious disease in animals

迫切需要低成本、便携和快速的筛查工具，以检测动物疾病（如蓝舌病和动物流行性出血性疾病）并预防重大疫情。血清学检测是检测传染病最合适的方法。然而，大多数血清学检测仍在集中实验室设施中进行。除了测试成本之外，样品收集和运输还会增加额外的费用，并且等待结果的时间可能很长。我们建议扩展我们现有的基于点护理（POC）阻抗的技术，以在20分钟内诊断蓝舌病和动物流行性出血性疾病感染，每次检测不到20美元。我们将与加拿大食品检验局（CFIA）合作，针对现有的1000个阴性和300个阳性血清样本进行血清学测试，验证我们的POC设备的性能。我们的目标是让兽医在现场使用该设备来监测潜在的大流行病爆发，也为国家流行病管理应急委员会使用。这是一种平台技术，可用于监测令人关注的病毒（禽流感病毒和新城疫）。

There is an urgent need for low-cost, portable, and rapid screening tools to detect animal diseases (such as bluetongue and epizootic hemorrhagic disease) and prevent major outbreaks. Serological testing is the most appropriate method to detect the presence of infectious diseases. However, most serological tests are still performed in a centralized laboratory facility. In addition to the cost of the test, sample collection and shipping impose additional expenses, and wait time for results can be lengthy. We are proposing to extend our existing point-of-care (POC) impedance-based technology to diagnose bluetongue and epizootic hemorrhagic disease infection within 20 minutes for less than $20 per test. We will partner with the Canadian Food Inspection Agency (CFIA) to validate the performance of our POC device against existing serology tests with 1000 negative and 300 positive sera samples. We aim for veterinaries to use the device on site for monitoring potential pandemic outbreaks, and also for the national emergency board for pandemic management. This is a platform technology and can be adapted for use to monitor viruses of concern (Avian influenza virus and Newcastle Diseases).