Point-of-care impedance-based technology to diagnose important infectious disease in animals

基于阻抗的即时护理技术诊断动物重要传染病

• 批准号: 570772-2021
• 负责人: Chen, Jie
• 金额: $ 9.11万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=722426
• 关键词: Point; care; impedance; based; technology

There is an urgent need for low-cost, portable, and rapid screening tools to detect animal diseases (such as bluetongue and epizootic hemorrhagic disease) and prevent major outbreaks. Serological testing is the most appropriate method to detect the presence of infectious diseases. However, most serological tests are still performed in a centralized laboratory facility. In addition to the cost of the test, sample collection and shipping impose additional expenses, and wait time for results can be lengthy. We are proposing to extend our existing point-of-care (POC) impedance-based technology to diagnose bluetongue and epizootic hemorrhagic disease infection within 20 minutes for less than $20 per test. We will partner with the Canadian Food Inspection Agency (CFIA) to validate the performance of our POC device against existing serology tests with 1000 negative and 300 positive sera samples. We aim for veterinaries to use the device on site for monitoring potential pandemic outbreaks, and also for the national emergency board for pandemic management. This is a platform technology and can be adapted for use to monitor viruses of concern (Avian influenza virus and Newcastle Diseases).

迫切需要低成本、便携式和快速的筛查工具来检测动物疾病（如蓝舌病和动物流行性出血性疾病）并预防重大疫情。血清学检测是检测传染病存在的最适当方法。然而，大多数血清学检测仍在集中实验室设施进行。除了测试的成本之外，样本收集和运输还需要额外的费用，并且等待结果的时间可能很长。我们建议扩展我们现有的基于阻抗的护理点（POC）技术，以在20分钟内诊断蓝舌病和动物流行性出血性疾病感染，每次测试不到20美元。我们将与加拿大食品检验局（CFIA）合作，利用1000份阴性和300份阳性血清样本验证我们的POC设备对现有血清学检测的性能。我们的目标是让兽医在现场使用该设备监测潜在的大流行爆发，也让国家应急委员会进行大流行管理。这是一种平台技术，可用于监测关注病毒（禽流感病毒和纽卡斯尔病）。