Understanding the role of conformational dynamics in the substrate promiscuity of the Pup-proteasome system in mycobacteria
Understanding the role of conformational dynamics in the substrate promiscuity of the Pup-proteasome system in mycobacteria
批准号:
486236
负责人:
Plourde Alicia
金额:
$1.27万
依托单位:
依托单位国家:
加拿大
项目类别:
Studentship Programs
财政年份:
2022
资助国家:
加拿大
项目状态:
已结题
起止时间:
2022-12-01 至 2023-12-01
中文摘要
结核病(TB)是世界范围内由单一传染源引起的第二大致命疾病。结核病耐药性病例的惊人增加迫切需要具有新作用模式的新型疗法。蛋白质降解途径
英文摘要
Tuberculosis (TB) is the second deadliest disease from a single infectious agent worldwide. An alarming increase in antimicrobial resistant cases of TB calls on a dire need for novel therapeutics with new modes of action. A protein degradation pathway in
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