A handheld multi-material pen for in situ tissue engineering

体外组织打印（也称为生物打印）的临床翻译面临几个障碍，包括1)使用医学图像和计算机辅助设计软件重建目标组织的繁琐和耗时的过程，2)需要模拟人体生理条件的生物反应器，以促进植入前的组织生长和成熟，以及3)在操作和处理过程中组织污染的高风险。为了克服这些障碍，我们创造了一种便携式生物打印设备，能够沉积多种生物墨水，包括光交联、化学固化和纳米复合生物墨水，并能精确控制其时空和物理化学性质。在这个提案中，我们打算通过进行全面的市场分析来评估市场规模、潜在客户和市场壁垒，从而将这项技术商业化。

Clinical translation of ex vivo tissue printing (also known as bioprinting) faces several obstacles, including 1) the tedious and time-consuming process of reconstructing the target tissue using medical images and computer-aided design software, 2) the need for bioreactors that mimic human physiological conditions to facilitate tissue growth and maturation prior to implantation, and 3) the high risk of tissue contamination during manipulation and handling. In order to overcome these obstacles, we have created a portable bioprinting device capable of depositing numerous bioinks including photcrosslinkable, chemically curable, and nanocomposite bioinks with precise control over their spatiotemporal and physicochemical properties. In this proposal, we intend to commercialize this technology by doing a thorough market analysis to evaluate market size, possible customers, and market barriers.