多病种言语性幻听症状影像遗传学特征及治疗靶点的模式识别研究

言语性幻听特指在确无外界现实声音刺激的条件下，患者体验到有针对自己的“真实声音”存在，多数“声音”给患者带来精神痛苦，是高致残致死性精神症状之一。言语性幻听可出现于多种精神障碍患者，极易导致疾病的误诊误治。因此，探寻言语性幻听的病理特征和精准治疗靶点已经成为当前亟需解决的科学问题。本项目拟联合基于高通量测序的基因组学技术和基于脑影像的脑连接组学技术，探索精神分裂症、双相障碍、单相抑郁、创伤后应激障碍、边缘型人格障碍患者和健康者6类人群的言语性幻听症状的影像遗传学特征，并采用模式识别技术，建立不同病种言语性幻听早期定性诊断和疗效预测体系，从内源性遗传特征（基因）-内表型特征（脑环路/脑网络）-表型特征（临床表现）三个层面揭示不同病种言语性幻听共性及特异性影像遗传学特征，探索不同病种言语性幻听的精准治疗靶点，解决科学问题和临床难题。

Auditory verbal hallucinations (AVH) refer in particular to the “real sounds” that patients perceived by themselves without auditory stimulus of external reality. As one of the psychotic symptoms, most “sounds” bring mental suffering to patients and lead to high disability and mortality. AVH can be seen in patients with various mental disorders, which can lead to misdiagnosis and mistreatment easily. Therefore, exploring the pathological characteristics and precise therapeutic target of AVH has become an urgent scientific problem. Combining both genomics technology based on high-throughput sequencing and brain network technology based on brain imaging, 6 groups of participants with AVH will be enrolled in this study, including schizophrenia, bipolar disorder, unipolar depression, borderline personality disorder,posttraumatic stress disorder and healthy people. Further, pattern recognition technology will be adopted to establish early diagnosis and therapeutic effect prediction models for AVH in different mental illnesses. Based on three levels, the endogenous genetic characteristics-endophenotypic characteristics (brain network)-clinical phenotypic characteristics (clinical manifestations), the study will reveal the general and specific imaging genetic characteristics, explore the precise therapeutic target and solve scientific and clinical problems.