Host defense pathways: role of redundancy and compensation in infectious disease phenotypes.

Host defense pathways: role of redundancy and compensation in infectious disease phenotypes.
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宿主防御途径:冗余和补偿在传染病表型中的作用。

DOI:
10.1016/j.immuni.2011.05.009
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发表时间:
2011-05-27
期刊:
影响因子:
32.4
通讯作者:
Medzhitov R
Medzhitov R
中科院分区:
医学1区
文献类型:
--
作者:
Nish S;Medzhitov R

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宿主天然防御途径包括微生物传感器、信号转导途径和抗微生物效应机制。目前已知有几类宿主防御途径,每一类都包含几种检测不同类型病原体的模式识别受体。这些途径以各种方式相互作用,可以分为合作,互补和补偿。理解这些相互作用的原理对于更好地理解宿主防御机制以及正确解释免疫缺陷表型是重要的。
Innate host defense pathways consist of microbial sensors, their signaling pathways and the anti-microbial effector mechanisms. Several classes of host defense pathways are currently known, each comprising several pattern-recognition receptors that detect different types of pathogens. These pathways interact with one another in a variety of ways that can be categorized into cooperation, complementation and compensation. Understanding the principles of these interactions is important for better understanding of host defense mechanisms, as well as for correct interpretation of immunodeficient phenotypes.
RIG-I 样受体的免疫信号传导。
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