Host defense pathways: role of redundancy and compensation in infectious disease phenotypes.
Host defense pathways: role of redundancy and compensation in infectious disease phenotypes.
复制标题
宿主防御途径:冗余和补偿在传染病表型中的作用。
DOI:
10.1016/j.immuni.2011.05.009
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发表时间:
2011-05-27
期刊:
影响因子:
32.4
通讯作者:
Medzhitov R
中科院分区:
文献类型:
--
作者:
Nish S;Medzhitov R
Innate host defense pathways consist of microbial sensors, their signaling pathways and the anti-microbial effector mechanisms. Several classes of host defense pathways are currently known, each comprising several pattern-recognition receptors that detect different types of pathogens. These pathways interact with one another in a variety of ways that can be categorized into cooperation, complementation and compensation. Understanding the principles of these interactions is important for better understanding of host defense mechanisms, as well as for correct interpretation of immunodeficient phenotypes.
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DOI:
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发表时间:
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期刊:
Science (New York, N.Y.)
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