Effect of Cystone® on urinary composition and stone formation over a one year period.
Effect of Cystone® on urinary composition and stone formation over a one year period.
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DOI：
10.1016/j.phymed.2011.01.018
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发表时间：
2011-07-15
期刊：
影响因子：
--
通讯作者：
Lieske JC
中科院分区：
文献类型：
--
作者：
Erickson SB;Vrtiska TJ;Lieske JC
肾结石是一种常见的疾病，预防不足。我们招募了10名患有草酸钙结石的复发性肾结石患者，进行了一项两阶段研究，以评估Cystone®的安全性和有效性，Cystone®是一种预防肾结石的草药治疗。第一阶段是随机双盲12周交叉研究，评估Cystone®对比安慰剂对尿过饱和的影响。第二阶段是一项为期一年的Cystone®开放标签研究，以确定肾结石负荷是否减少，通过CT的定量和主观评估进行评估。结果显示，Cystone®对短期（6周）或长期（52周）的尿液成分无统计学显著影响。Cystone®治疗后平均肾结石负荷增加而非减少。因此，本研究不支持Cystone®治疗草酸钙结石形成者的疗效。未来的研究将需要评估对结石通过或其他结石类型的影响。
Kidney stones are a common problem for which inadequate prevention exists. We recruited ten recurrent kidney stone formers with documented calcium oxalate stones into a two phased study to assess safety and effectiveness of Cystone®, an herbal treatment for prevention of kidney stones. The first phase was a randomized double-blinded 12 week cross over study assessing the effect of Cystone® vs. placebo on urinary supersaturation. The second phase was an open label one year study of Cystone® to determine if renal stone burden decreased, as assessed by quantitative and subjective assessment of CT. Results revealed no statistically significant effect of Cystone® on urinary composition short (6 weeks) or long (52 weeks) term. Average renal stone burden increased rather than decreased on Cystone®. Therefore, this study does not support the efficacy of Cystone® to treat calcium oxalate stone formers. Future studies will be needed to assess effects on stone passage, or on other stone types.
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影响因子：
5.4
作者：
Atmani, F;Slimani, Y;Ziyyat, A
通讯作者：
Ziyyat, A
DOI：
10.1111/j.1442-2042.1995.tb00429.x
发表时间：
1995-05-01
期刊：
International journal of urology : official journal of the Japanese Urological Association
影响因子：
--
作者：
Koide, T;Yamaguchi, S;Sugiyama, K
通讯作者：
Sugiyama, K
影响因子：
6.6
作者：
Ettinger, B;Pak, CYC;Vangessel, A
通讯作者：
Vangessel, A
影响因子：
2.5
作者：
Campos, AH;Schor, N
通讯作者：
Schor, N
影响因子：
19.6
作者：
Parks, JH;Coward, M;Coe, FL
通讯作者：
Coe, FL