Alcohol consumption from midlife and risk of disabling dementia in a large population‐based cohort study in Japan
Alcohol consumption from midlife and risk of disabling dementia in a large population‐based cohort study in Japan
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日本一项基于人群的大型队列研究中中年饮酒与致残性痴呆的风险
DOI：
10.1002/gps.5896
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发表时间：
2023
影响因子：
4
通讯作者：
Tsugane S
中科院分区：
文献类型：
--
作者：
Shimizu Y;Sawada N;Ihira H;Abe SK;Inoue M;Yasuda N;Yamagishi K;Iwasaki M;Tsugane S
日本人饮酒与痴呆症之间的联系知之甚少，使用单点酒精评估可能会导致测量误差。我们通过重复酒精评估在日本人中探索了这种联系。方法自1990年以来，日本公共卫生中心前瞻性研究(JPHC研究)的参与者从2006年到2016年被跟踪调查，以确定是否患有痴呆症。致残痴呆症是通过长期护理保险记录确定的。在为期5年的问卷调查(1995-1999年)中评估饮酒情况，并在重复随访(2000-2003年)中评估饮酒模式。我们进行了以年龄为时间尺度的Cox比例风险模型，调整了各种生活方式因素和病史，以轻度饮酒(<；75g酒精/周，以下简称“g”)为参考。结果在42,870名年龄在54-84岁的参与者中，新诊断出4802例致残性痴呆。从酒精评估到痴呆症发病率的平均年限为14.9年。不饮酒者和5年后≥为450g的经常饮酒者调整后的HR(95%CI)分别为1.29(1.12-1.47)和1.34(1.12-1.60)。长期戒酒、既往饮酒和每周经常大量摄入≥450g的模式显示，调整后的RR分别增加了1.61(1.28-2.03)、2.54(1.93-3.35)和1.96(1.49-2.59)。相互竞争的风险分析得出了类似的结果。结论在日本，与少量饮酒相比，不饮酒和中年定期饮用≥450g与致残痴呆症的风险更高。
ObjectivesThe association between alcohol consumption and dementia in Japanese is poorly understood, and use of single‐point alcohol assessment may cause measurement error. We explored this association in Japanese using repeated alcohol assessments.MethodsParticipants in the Japan Public Health Center‐based Prospective Study (JPHC Study) since 1990 and who were alive in 2006 were followed from 2006 until 2016 for dementia ascertainment. Disabling dementia was identified through long‐term care insurance records. Alcohol consumption was assessed at the 5‐year questionnaire survey (1995–1999) and drinking patterns were assessed on repeated follow‐up (2000–2003). We performed Cox proportional hazards models with age as the time‐scale with adjustment for various lifestyle factors and medical history using light consumption (<75 g ethanol/week, hereinafter “g”) as reference. Analysis considering death as a competing risk was also conducted.ResultsAmong 42,870 participants aged 54–84 years, 4802 cases of disabling dementia were newly diagnosed. Average years from alcohol assessment until dementia incidence was 14.9 years. Non‐drinkers and regular drinkers with ≥450 g at 5 years had adjusted HRs (95% CI) of 1.29 (1.12–1.47) and 1.34 (1.12–1.60). Patterns of long‐term abstinence, former drinking, and regular heavy weekly consumption of ≥450 g showed increased adjusted HRs of 1.61 (1.28–2.03), 2.54 (1.93–3.35), and 1.96 (1.49–2.59), respectively. Competing risk analysis yielded similar results.ConclusionsIn Japanese, non‐drinking and regular weekly consumption of ≥450 g from midlife were associated with high risk of disabling dementia compared with light drinking.
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影响因子：
2
作者：
Thiébaut, ACM;Bénichou, J
通讯作者：
Bénichou, J
影响因子：
13.6
作者：
Xu, Wei;Wang, Huifu;Yu, Jin-Tai
通讯作者：
Yu, Jin-Tai
DOI：
10.1111/j.1530-0277.1996.tb01080.x
发表时间：
1996-05-01
影响因子：
3.2
作者：
Higuchi, S;Matsushita, S;Hayashida, M
通讯作者：
Hayashida, M
DOI：
10.15288/jsa.1992.53.170
发表时间：
1992-03-01
期刊：
JOURNAL OF STUDIES ON ALCOHOL
影响因子：
--
作者：
HIGUCHI, S;MURAMATSU, T;HARFORD, TC
通讯作者：
HARFORD, TC
影响因子：
39.3
作者：
Yamagishi, Kazumasa;Iso, Hiroyasu;Tsugane, Shoichiro
通讯作者：
Tsugane, Shoichiro