Gene acquisition convergence between entomopoxviruses and baculoviruses.
Gene acquisition convergence between entomopoxviruses and baculoviruses.
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DOI：
10.3390/v7041960
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发表时间：
2015-04-13
期刊：
影响因子：
--
通讯作者：
Herniou EA
中科院分区：
文献类型：
--
作者：
Thézé J;Takatsuka J;Nakai M;Arif B;Herniou EA
来自不同系统发育起源的生物可以在相同的生态位中茁壮成长。它们可能会被诱导进化出趋同适应，以应对类似的选择压力。它们的基因组应该带有这一过程的特征。对感染相同宿主的不相关病毒谱系的研究保证了对系统独立的会聚适应的明确鉴定。在这里，我们调查的附属基因组中的基因的进化历史的不相关的昆虫大双链DNA病毒：昆虫痘病毒（EPVs，痘病毒科）和杆状病毒（BV）。EPVs和BV具有重叠的生态位，并且独立地进化出类似的感染过程。从理论上讲，它们受到来自宿主免疫反应的相同选择压力。因此，它们的附属基因组可能具有类似的趋同适应的基因组特征，并可能指出迄今在病毒中未发现的关键适应基因组机制。我们发现了32个同源的，但独立收购的基因来源于昆虫宿主，不同的真核生物，细菌和病毒。我们在这些病毒中发现了不同进化水平的基因获取趋同，强调了一个连续的进化过程。我们发现，无论是最近的和古老的基因收购可能涉及到适应特定的和远亲的主机。多方向和多部分的基因交换网络似乎不断驱动外源基因同化，带来关键的适应性创新，并塑造大型DNA病毒的生活史。这种进化过程可能导致基因组水平的适应性收敛。
Organisms from diverse phylogenetic origins can thrive within the same ecological niches. They might be induced to evolve convergent adaptations in response to a similar landscape of selective pressures. Their genomes should bear the signature of this process. The study of unrelated virus lineages infecting the same host panels guarantees a clear identification of phyletically independent convergent adaptation. Here, we investigate the evolutionary history of genes in the accessory genome shared by unrelated insect large dsDNA viruses: the entomopoxviruses (EPVs, Poxviridae) and the baculoviruses (BVs). EPVs and BVs have overlapping ecological niches and have independently evolved similar infection processes. They are, in theory, subjected to the same selective pressures from their host’s immune responses. Their accessory genomes might, therefore, bear analogous genomic signatures of convergent adaption and could point out key genomic mechanisms of adaptation hitherto undetected in viruses. We uncovered 32 homologous, yet independent acquisitions of genes originating from insect hosts, different eukaryotes, bacteria and viruses. We showed different evolutionary levels of gene acquisition convergence in these viruses, underlining a continuous evolutionary process. We found both recent and ancient gene acquisitions possibly involved to the adaptation to both specific and distantly related hosts. Multidirectional and multipartite gene exchange networks appear to constantly drive exogenous gene assimilations, bringing key adaptive innovations and shaping the life histories of large DNA viruses. This evolutionary process might lead to genome level adaptive convergence.
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