Embedded Multimaterial Extrusion Bioprinting.
Embedded Multimaterial Extrusion Bioprinting.
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DOI：
10.1177/2472630317742071
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发表时间：
2018-04
期刊：
影响因子：
2.7
通讯作者：
Zhang YS
中科院分区：
文献类型：
--
作者：
Rocca M;Fragasso A;Liu W;Heinrich MA;Zhang YS
嵌入式挤出生物打印允许通过克服重力施加的限制来产生复杂结构，否则这些复杂结构无法通过传统的从底部逐层沉积来实现。通过利用水凝胶浴，用作牺牲打印环境，以自由形式挤出生物墨水直到整个结构被沉积和交联是可行的。生物打印的结构随后可以从支撑水凝胶释放并用于进一步的应用。将这种先进的三维（3D）生物打印技术与多材料挤出打印头设置相结合，可以制造由多种生物墨水构建的复杂体积结构。本文所述的工作重点是实验装置的优化，并提出了一个工作流程，以自动化的生物打印过程，导致一个虚拟的3D模型的快速和有效的转换成一个物理的，挤压结构的自由形式使用的多材料嵌入式生物打印系统。预计该技术的进一步发展将可能导致在组织工程、药物测试和芯片上器官等领域的广泛应用。
Embedded extrusion bioprinting allows for the generation of complex structures that otherwise cannot be achieved with conventional layer-by-layer deposition from the bottom, by overcoming the limits imposed by gravitational force. By taking advantage of a hydrogel bath, serving as a sacrificial printing environment, it is feasible to extrude a bioink in freeform until the entire structure is deposited and crosslinked. The bioprinted structure can be subsequently released from the supporting hydrogel and used for further applications. Combining this advanced three-dimensional (3D) bioprinting technique with a multimaterial extrusion printhead setup enables the fabrication of complex volumetric structures built from multiple bioinks. The work described in this paper focuses on the optimization of the experimental setup and proposes a workflow to automate the bioprinting process, resulting in a fast and efficient conversion of a virtual 3D model into a physical, extruded structure in freeform using the multimaterial embedded bioprinting system. It is anticipated that further development of this technology will likely lead to widespread applications in areas such as tissue engineering, pharmaceutical testing, and organs-on-chips.
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影响因子：
13.6
作者：
Hinton TJ;Jallerat Q;Palchesko RN;Park JH;Grodzicki MS;Shue HJ;Ramadan MH;Hudson AR;Feinberg AW
通讯作者：
Feinberg AW
影响因子：
--
作者：
Dhariwala, B;Hunt, E;Boland, T
通讯作者：
Boland, T
DOI：
10.1002/adma.201604630
发表时间：
2017-01
期刊：
Advanced materials (Deerfield Beach, Fla.)
影响因子：
--
作者：
Liu W;Zhang YS;Heinrich MA;De Ferrari F;Jang HL;Bakht SM;Alvarez MM;Yang J;Li YC;Trujillo-de Santiago G;Miri AK;Zhu K;Khoshakhlagh P;Prakash G;Cheng H;Guan X;Zhong Z;Ju J;Zhu GH;Jin X;Shin SR;Dokmeci MR;Khademhosseini A
通讯作者：
Khademhosseini A
影响因子：
46.9
作者：
Kang, Hyun-Wook;Lee, Sang Jin;Atala, Anthony
通讯作者：
Atala, Anthony
影响因子：
--
作者：
Cohen, Daniel L.;Malone, Evan;Bonassar, Lawrence J.
通讯作者：
Bonassar, Lawrence J.