Doped tricalcium phosphate scaffolds by thermal decomposition of naphthalene: Mechanical properties and in vivo osteogenesis in a rabbit femur model.
Doped tricalcium phosphate scaffolds by thermal decomposition of naphthalene: Mechanical properties and in vivo osteogenesis in a rabbit femur model.
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DOI：
10.1002/jbm.b.33321
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发表时间：
2015-11
影响因子：
3.4
通讯作者：
Bose, Susmita
中科院分区：
文献类型：
--
作者：
Ke, Dongxu;Dernell, William;Bandyopadhyay, Amit;Bose, Susmita
磷酸三钙（TCP）是一种广泛用于骨科和牙科应用的生物陶瓷。TCP结构显示出优异的生物相容性以及生物降解性。本研究采用萘热分解法制备多孔β-TCP支架。在1150°C下去除30%萘后，可得到密度为57.64 ± 3.54%、最大孔径约为100 μm的多孔支架。这些支架的抗压强度为32.85 ± 1.41 MPa。此外，通过混合1wt%SrO和0.5wt%SiO2，孔互连性改善，但压缩强度降低至22.40 ± 2.70MPa。然而，在添加聚己内酯（PCL）涂层后，掺杂支架的压缩强度增加到29.57 ± 3.77 MPa。将多孔支架植入兔股骨缺损，评价其生物学性能。添加掺杂剂通过促进类骨质形成、骨钙素表达和骨再生，尤其是在支架和宿主骨的界面处，触发骨诱导。该研究显示了制造具有不同孔径和体积分数孔隙率的互连多孔支架的工艺灵活性，该多孔支架具有高压缩机械强度和更好的生物活性。结果表明，SrO/SiO2掺杂多孔TCP支架具有良好的潜力，用于骨组织工程的应用。
Tricalcium phosphate (TCP) is a bioceramic that is widely used in orthopedic and dental applications. TCP structures show excellent biocompatibility as well as biodegradability. In this study, porous β-TCP scaffolds were prepared by thermal decomposition of naphthalene. Scaffolds with 57.64 ± 3.54 % density and a maximum pore size around 100 μm were fabricated via removing 30% naphthalene at 1150°C. The compressive strength for these scaffolds was 32.85 ± 1.41 MPa. Furthermore, by mixing 1 wt % SrO and 0.5 wt % SiO2, pore interconnectivity improved, but the compressive strength decreased to 22.40 ± 2.70 MPa. However, after addition of polycaprolactone (PCL) coating layers, the compressive strength of doped scaffolds increased to 29.57 ± 3.77 MPa. Porous scaffolds were implanted in rabbit femur defects to evaluate their biological property. The addition of dopants triggered osteoinduction by enhancing osteoid formation, osteocalcin expression and bone regeneration, especially at the interface of the scaffold and host bone. This study showed processing flexibility to make interconnected porous scaffolds with different pore size and volume fraction porosity with high compressive mechanical strength and better bioactivity. Results show that SrO/SiO2 doped porous TCP scaffolds have excellent potential to be used in bone tissue engineering applications.
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