Environmental exposure to metals and male reproductive hormones: circulating testosterone is inversely associated with blood molybdenum.
Environmental exposure to metals and male reproductive hormones: circulating testosterone is inversely associated with blood molybdenum.
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DOI：
10.1016/j.fertnstert.2008.09.044
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发表时间：
2010-01
影响因子：
6.7
通讯作者：
Wirth JJ
中科院分区：
文献类型：
--
作者：
Meeker JD;Rossano MG;Protas B;Padmanahban V;Diamond MP;Puscheck E;Daly D;Paneth N;Wirth JJ
探讨金属接触与男性生殖激素水平之间的关系。调整潜在混杂因素的横断面流行病学研究。金属浓度和生殖激素水平的血液样本收集了219名男子。患者：通过两个密歇根州，美国不孕症诊所招募的男性。无血清FSH、LH、FSH B、睾酮和SHBG。当单独建模时，镉、铜和铅均与睾酮显著或显著正相关（p值分别为0.1、0.03和0.07），这些发现与有限的既往人类和动物研究一致。相反，钼与睾酮降低相关（趋势p值= 0.001）。当在模型中额外考虑其他金属时，钼和睾酮之间的显着反向趋势仍然存在，其中睾酮和锌之间的正相关性也被发现。最后，在探索性分析中，有证据表明钼和锌之间的相互作用，其中高钼与低锌男性睾酮降低37%（相对于人口中位数水平）相关。虽然之前在动物研究中已经证明了钼暴露后睾酮和生殖毒性的降低，但需要更多的研究来确定钼是否对人类生殖健康构成风险。
To explore associations between exposure to metals and male reproductive hormone levels. Cross-sectional epidemiology study with adjustment for potential confounders. Metal concentrations and reproductive hormone levels were measured in blood samples collected from 219 men. Patients: Men recruited through two Michigan, USA infertility clinics. None Serum FSH, LH, inhibin B, testosterone, and SHBG. Cadmium, copper and lead were all significantly or suggestively positively associated with testosterone when modeled individually (p-values = 0.1, 0.03, and 0.07, respectively), findings that are consistent with limited previous human and animal studies. Conversely, molybdenum was associated with reduced testosterone (p-value for trend = 0.001). A significant inverse trend between molybdenum and testosterone remained when additionally considering other metals in the model, where a positive association between testosterone and zinc was also found. Finally, in exploratory analysis there was evidence for an interaction between molybdenum and zinc, where high molybdenum was associated with a 37% reduction in testosterone (relative to the population median level) among men with low zinc. While reductions in testosterone and reproductive toxicity following molybdenum exposure have been previously demonstrated in animal studies, more research is needed to determine whether molybdenum poses a risk to human reproductive health.
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DOI：
10.1080/00039890109604481
发表时间：
2001-09-01
期刊：
ARCHIVES OF ENVIRONMENTAL HEALTH
影响因子：
--
作者：
Erfurth, EM;Gerhardsson, L;Börjesson, J
通讯作者：
Börjesson, J
影响因子：
3.6
作者：
Haywood, S;Dincer, Z;Parry, NM
通讯作者：
Parry, NM
DOI：
10.1081/clt-100102422
发表时间：
1999-01-01
期刊：
JOURNAL OF TOXICOLOGY-CLINICAL TOXICOLOGY
影响因子：
--
作者：
Barceloux, DG
通讯作者：
Barceloux, DG
影响因子：
5.8
作者：
Groome, NP;Illingworth, PJ;McNeilly, AS
通讯作者：
McNeilly, AS
DOI：
10.1080/00039896.1968.10665069
发表时间：
1968-01-01
期刊：
ARCHIVES OF ENVIRONMENTAL HEALTH
影响因子：
--
作者：
ALLAWAY, WH;KUBOTA, J;ROTH, M
通讯作者：
ROTH, M