Integrative Metabolomics to Identify Molecular Signatures of Responses to Vaccines and Infections.
Integrative Metabolomics to Identify Molecular Signatures of Responses to Vaccines and Infections.
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DOI：
10.3390/metabo10120492
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发表时间：
2020-11-30
期刊：
影响因子：
4.1
通讯作者：
Levy O
中科院分区：
文献类型：
--
作者：
Diray-Arce J;Conti MG;Petrova B;Kanarek N;Angelidou A;Levy O
代谢物的鉴定方法已经从早期的生化途径评估发展到现代高维代谢组学，这是识别和表征健康和疾病生物标志物的强大工具。除了与经典代谢疾病的相关性之外，代谢组学也是免疫代谢出现的关键，免疫代谢是一个重要的研究领域，因为白细胞产生对先天性和适应性免疫很重要的关键代谢物并受到其影响。在此，我们讨论感染和疫苗接种过程中人类免疫系统激活所扰乱的代谢组学特征和途径。例如，感染会引起脂质（例如游离脂肪酸、鞘脂和溶血磷脂酰胆碱）和氨基酸途径（例如色氨酸、丝氨酸和苏氨酸）的变化，而疫苗接种可以引发碳水化合物和胆汁酸途径的变化。氨基酸、碳水化合物、脂质和核苷酸代谢与免疫相关，并受到感染和疫苗接种的干扰。代谢组学有望为宿主免疫反应的分子机制提供新的见解。其与其他系统生物学平台的集成将加强对人类健康和疾病的研究。
Approaches to the identification of metabolites have progressed from early biochemical pathway evaluation to modern high-dimensional metabolomics, a powerful tool to identify and characterize biomarkers of health and disease. In addition to its relevance to classic metabolic diseases, metabolomics has been key to the emergence of immunometabolism, an important area of study, as leukocytes generate and are impacted by key metabolites important to innate and adaptive immunity. Herein, we discuss the metabolomic signatures and pathways perturbed by the activation of the human immune system during infection and vaccination. For example, infection induces changes in lipid (e.g., free fatty acids, sphingolipids, and lysophosphatidylcholines) and amino acid pathways (e.g., tryptophan, serine, and threonine), while vaccination can trigger changes in carbohydrate and bile acid pathways. Amino acid, carbohydrate, lipid, and nucleotide metabolism is relevant to immunity and is perturbed by both infections and vaccinations. Metabolomics holds substantial promise to provide fresh insight into the molecular mechanisms underlying the host immune response. Its integration with other systems biology platforms will enhance studies of human health and disease.
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影响因子：
4.8
作者：
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DOI：
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64.5
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DOI：
10.4168/aair.2010.2.2.127
发表时间：
2010-04
期刊：
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影响因子：
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作者：
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Hong SJ