Oxidative status in dairy goats: periparturient variation and changes in subclinical hyperketonemia and hypocalcemia.
Oxidative status in dairy goats: periparturient variation and changes in subclinical hyperketonemia and hypocalcemia.
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奶山羊的氧化状态：围产期变异以及亚临床高酮血症和低钙血症的变化
DOI：
10.1186/s12917-021-02947-1
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发表时间：
2021-07-06
影响因子：
2.6
通讯作者：
Wang J
中科院分区：
文献类型：
--
作者：
Huang Y;Wen J;Kong Y;Zhao C;Liu S;Liu Y;Li L;Yang J;Zhu X;Zhao B;Cao B;Wang J
更好地了解围产期的氧化还原状态，可能有助于管理和营养解决方案的发展，以防止奶山羊亚临床高酮血症（SCHK）和亚临床低钙血症（SCHC）。我们的目的是评估的变化，氧化还原状态的奶山羊与SCHK和SCHC在其围产期。将30只关中奶山羊随机分为SCHK（n = 10）、SCHC（n = 10）和健康（HEAL，n = 10）3组，每组10只。从预期分娩日期前3周至产后3周，每周从山羊中抽取血液。在同一天，评估身体状况评分（BCS），并记录每只山羊的产奶量。通过使用标准生化技术测定代谢谱参数和氧化状态指标。与HEAL山羊相比，SCHK和SCHC山羊在产后2周和3周的产奶量显著下降，而1周的产奶量显著增加。非酯化脂肪酸（NEFA）的水平在分娩时达到峰值，SCHK和SCHC组从产后1周到分娩日的水平显著较高。从产前1周到产后3周，SCHK山羊体内丙二醛（MDA）浓度均呈上升趋势，SCHC山羊分娩时MDA浓度显著高于对照组。过氧化氢（H2 O2）的浓度显着降低，在SCHK和SCHC山羊从产前2周至产后1周。SCHK和SCHC山羊的总抗氧化能力（T-AOC）和超氧化物歧化酶（SOD）水平分别在产前1周时下降。在泌乳早期，SCHK和SCHC山羊的谷胱甘肽过氧化物酶（GSH-Px）水平升高。SCHK和SCHC山羊在围产期比HEAL山羊更努力地维持氧化还原稳态，以确保生产性能，这可能是由于前者更强烈的脂肪动员和脂质过氧化作用。
A better comprehension of the redox status during the periparturient period may facilitate the development of management and nutritional solutions to prevent subclinical hyperketonemia (SCHK) and subclinical hypocalcemia (SCHC) in dairy goats. We aimed to evaluate the variation in the redox status of dairy goats with SCHK and SCHC during their periparturient periods. Guanzhong dairy goats (n = 30) were assigned to SCHK (n = 10), SCHC (n = 10), and healthy (HEAL, n = 10) groups based on their blood β-hydroxybutyrate (BHBA) and calcium (Ca) concentrations. Blood were withdrawn from goats every week from 3 weeks before the expected parturition date to 3 weeks post-kidding. On the same day, the body condition scores (BCS) were evaluated, and the milk yield was recorded for each goat. The metabolic profile parameters and the indicators of oxidative status were determined by using the standard biochemical techniques. In comparison with the HEAL goats, SCHK and SCHC goats presented with a more dramatic decline of BCS post-kidding and a significant decrease in the milk yield at 2- and 3-weeks postpartum, ignoring the obvious increase at 1-week postpartum. The levels of non-esterified fatty acids (NEFA) peaked at parturition, exhibiting significantly higher levels from 1-week prepartum to the parturition day in the SCHK and SCHC groups. The malondialdehyde (MDA) concentration was increased in the SCHK goats from 1-week antepartum until 3-weeks postpartum, with its concentration being significantly higher in the SCHC goats at parturition. The hydrogen peroxide (H2O2) concentration was significantly lower in the SCHK and SCHC goats from 2-weeks antepartum to 1-week post-kidding. The total antioxidant capacity (T-AOC) and the superoxide dismutase (SOD) level were decreased at 1-week antepartum in the SCHK and SCHC goats, respectively. The glutathione peroxidase (GSH-Px) level was increased in the SCHK and SCHC goats during the early lactation period. The SCHK and SCHC goats exerted more efforts to maintain their redox homeostasis and to ensure the production performance than the HEAL goats during their periparturient period, probably owing to more intense fat mobilization and lipid peroxidation in the former.
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影响因子：
2.2
作者：
Celi, Pietro;Di Trana, Adriana;Claps, Salvatore
通讯作者：
Claps, Salvatore
影响因子：
2.1
作者：
Ahmed, Eman A.;Elsayed, Doaa H.;El-Beltagy, Marwa A.
通讯作者：
El-Beltagy, Marwa A.
补充有机硒对足硒奶牛围产期硒状态、氧化应激和抗氧化状态的影响
影响因子：
3.9
作者：
Gong, Jian;Xiao, Min
通讯作者：
Xiao, Min
影响因子：
2.8
作者：
Ozarda, Yesim;Tuncer, Gul Ozlem;Eroz, Esma
通讯作者：
Eroz, Esma
影响因子：
4.6
作者：
Li, Peng;Li, Lanzhi;He, Jianbin
通讯作者：
He, Jianbin