Estimation of the pulmonary microvascular reflection coefficient to protein in dogs.
Estimation of the pulmonary microvascular reflection coefficient to protein in dogs.
复制标题
狗肺微血管对蛋白质的反射系数的估计。
DOI:
10.1152/jappl.1991.71.1.94
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发表时间:
1991
期刊:
影响因子:
--
通讯作者:
Gabel,JC
中科院分区:
文献类型:
--
作者:
Drake,RE;Gabel,JC
We used a new technique to estimate the pulmonary microvascular membrane reflection coefficient to plasma protein (sigma d) in anesthetized dogs. In five animals we continuously weighed the lower left lung lobe and used a left atrial balloon to increase the pulmonary microvascular pressure (Pc). We determined the relationship between the rate of edema formation (S) and Pc and estimated the fluid filtration coefficient (Kf) as delta S/delta Pc. From the S vs. Pc relationship and Kf, we estimated the Pc at which S/Kf = 10 mmHg for each dog. This pressure (P10) was 38.0 +/- 5.8 (SD) mmHg, and the plasma protein osmotic pressure (pi c) was 14.9 +/- 3.7 mmHg. In five additional dogs in which we decreased pi c to 2.9 +/- 1.7 mmHg, P10 = 27.2 +/- 2.6 mmHg. The P10 vs. pi c regression line fit to the data from all 10 dogs was P10 = 0.92 pi c +/- 24.4 mmHg (r = 0.88). We estimated sigma d from the slope of the regression line as sigma d = square root of delta P10/delta pi c. With this technique, we estimated that, with 95% probability, sigma d lies between 0.72 and unity. This is higher than most previous sigma d estimates.
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作者:
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DOI:
10.1016/s0021-9673(00)86291-3
发表时间:
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期刊:
Journal of chromatography
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作者:
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作者:
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通讯作者:
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