Estimation of the pulmonary microvascular reflection coefficient to protein in dogs.

Estimation of the pulmonary microvascular reflection coefficient to protein in dogs.
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狗肺微血管对蛋白质的反射系数的估计。

DOI:
10.1152/jappl.1991.71.1.94
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发表时间:
1991
期刊:
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子:
--
通讯作者:
Gabel,JC
Gabel,JC
中科院分区:
--
文献类型:
--
作者:
Drake,RE;Gabel,JC

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我们用一种新的方法测定了麻醉犬肺微血管膜对血浆蛋白的反射系数(sigma d)。在5只动物中,我们连续称重左下肺叶,并使用左心房球囊增加肺微血管压(Pc)。我们确定了水肿形成速率(S)和Pc之间的关系,并估计了液体过滤系数(Kf)为Δ S/Δ Pc。根据S与Pc的关系和Kf,我们估计了每只犬S/Kf = 10 mmHg时的Pc。该压力(P10)为38.0 +/- 5.8(SD)mmHg,血浆蛋白渗透压(pic)为14.9 +/- 3.7 mmHg。在另外5只犬中,我们将pic降至2.9 +/- 1.7 mmHg,P10 = 27.2 +/- 2.6 mmHg。拟合所有10只犬数据的P10与pi c回归线为P10 = 0.92 pi c +/- 24.4 mmHg(r = 0.88)。我们从回归线的斜率估计sigma d为sigma d = delta P10/delta pi c的平方根。通过这种技术,我们估计,在95%的概率下,sigma d介于0.72和1之间。这比大多数以前的sigma d估计值都要高。
We used a new technique to estimate the pulmonary microvascular membrane reflection coefficient to plasma protein (sigma d) in anesthetized dogs. In five animals we continuously weighed the lower left lung lobe and used a left atrial balloon to increase the pulmonary microvascular pressure (Pc). We determined the relationship between the rate of edema formation (S) and Pc and estimated the fluid filtration coefficient (Kf) as delta S/delta Pc. From the S vs. Pc relationship and Kf, we estimated the Pc at which S/Kf = 10 mmHg for each dog. This pressure (P10) was 38.0 +/- 5.8 (SD) mmHg, and the plasma protein osmotic pressure (pi c) was 14.9 +/- 3.7 mmHg. In five additional dogs in which we decreased pi c to 2.9 +/- 1.7 mmHg, P10 = 27.2 +/- 2.6 mmHg. The P10 vs. pi c regression line fit to the data from all 10 dogs was P10 = 0.92 pi c +/- 24.4 mmHg (r = 0.88). We estimated sigma d from the slope of the regression line as sigma d = square root of delta P10/delta pi c. With this technique, we estimated that, with 95% probability, sigma d lies between 0.72 and unity. This is higher than most previous sigma d estimates.
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发表时间: 1982
影响因子: --
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影响因子: 7.8
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影响因子: --
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影响因子: 12.7
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发表时间: 1983-01-01
期刊: BIOCHEMISTRY
影响因子: 2.9
作者:
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