Recent insights into Candida albicans biofilm resistance mechanisms.
Recent insights into Candida albicans biofilm resistance mechanisms.
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DOI：
10.1007/s00294-013-0400-3
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发表时间：
2013-11
期刊：
影响因子：
2.5
通讯作者：
Van Dijck, Patrick
中科院分区：
文献类型：
--
作者：
Mathe, Lotte;Van Dijck, Patrick
像其他微生物一样，自由生活的白色念珠菌主要以三维多细胞结构存在，称为生物膜，而不是以浮游形式存在。白色念珠菌生物膜可以从宿主体内不同位置的非生物和生物表面分离出来。随着非生物植入物（主要是血液和导尿管）数量的增加，与生物膜相关的血液或泌尿生殖道感染的数量也在急剧增加，导致死亡率上升。生物膜结构内的细胞对特定常用抗真菌药物的敏感性降低，此外，最近的研究表明，这些细胞对免疫系统成分的杀伤不太敏感。在这篇综述中，我们总结了生物膜相关抗真菌药物耐药机制和免疫逃避策略的最重要见解，重点介绍了这一领域的最新研究进展。
Like other microorganisms, free-living Candida albicans is mainly present in a three-dimensional multicellular structure, which is called a biofilm, rather than in a planktonic form. Candida albicans biofilms can be isolated from both abiotic and biotic surfaces at various locations within the host. As the number of abiotic implants, mainly bloodstream and urinary catheters, has been increasing, the number of biofilm-associated bloodstream or urogenital tract infections is also strongly increasing resulting in a raise in mortality. Cells within a biofilm structure show a reduced susceptibility to specific commonly used antifungals and, in addition, it has recently been shown that such cells are less sensitive to killing by components of our immune system. In this review, we summarize the most important insights in the mechanisms underlying biofilm-associated antifungal drug resistance and immune evasion strategies, focusing on the most recent advances in this area of research.
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影响因子：
4.9
作者：
Bachmann, SP;VandeWalle, K;López-Ribot, JL
通讯作者：
López-Ribot, JL
影响因子：
3
作者：
Baillie, GS;Douglas, LJ
通讯作者：
Douglas, LJ
影响因子：
4.9
作者：
BENYAACOV, R;KNOLLER, S;KOLTIN, Y
通讯作者：
KOLTIN, Y
影响因子：
7.6
作者：
Chandra, J;Mukherjee, PK;Ghannoum, MA
通讯作者：
Ghannoum, MA
影响因子：
5.2
作者：
Chandra, Jyotsna;Long, Lisa;Mukherjee, Pranab K.
通讯作者：
Mukherjee, Pranab K.