Developmental change in the neurophysiological correlates of self-regulation in high- and low-emotion conditions.
Developmental change in the neurophysiological correlates of self-regulation in high- and low-emotion conditions.
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DOI：
10.1080/87565640903526512
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发表时间：
2010
影响因子：
1.5
通讯作者：
Lewis MD
中科院分区：
文献类型：
--
作者：
Lamm C;Lewis MD
童年最重要的任务之一是学会在负面情绪存在时进行自我调节。直到最近，几乎还没有研究探讨情绪自我调节在童年和青春期发展过程中的神经生理学相关性。我们有兴趣绘制 7 至 14 岁儿童在负面情绪背景下自我调节神经基础的细粒度发展概况。我们预测，随着年龄的增长，儿童为了自我调节而募集的皮质激活会减少，这反映出随着发育而神经效率的提高。我们还预测，随着负面情绪的增加，儿童会招募更多的皮质激活，这可能反映了对皮质资源的更大需求。我们通过情绪诱导阻滞执行 go/nogo 任务，并测量了 N2 的振幅，N2 是一种与抑制控制相关的事件相关电位，因为它随阻滞和年龄而变化。此外，我们估计了腹侧前额叶感兴趣区域（ROI；暗示眶额、腹内侧前额叶或头侧前扣带皮层激活）和背内侧前额叶 ROI（暗示背侧前扣带皮层激活）的激活，这些区域通常被建模为 N2 下的皮质发生器。结果显示，随着年龄的增长，中额叶头皮激活略有减少，但腹内侧前额叶 ROI 的激活减少更为明显。背内侧前额叶 ROI 激活没有与年龄相关的变化。最后，正如预测的那样，我们发现在负性情绪诱导期间腹侧前额叶 ROI 激活增加，可能反映了情绪调节背后的额皮质资源的更多募集，但这种激活的发育变化与其他条件没有什么不同。因此，随着年龄的增长，一般的自我调节和特别的情绪调节都会减少皮层激活，这表明皮层反应抑制机制更有效。
One of the most important tasks of childhood is learning to self-regulate in the presence of negative emotions. Until recently, almost no research has examined the neurophysiological correlates of emotional self-regulation as it develops over childhood and adolescence. We were interested in plotting a fine-grained developmental profile of the neural underpinnings of self-regulation, in the context of negative emotion, for 7- to 14-year-old children. We predicted that children would recruit less cortical activation with age in the service of self-regulation, reflecting increased neural efficiency with development. We also predicted that children would recruit more cortical activation with increased negative emotion, possibly reflecting greater demand on cortical resources. We administered a go/nogo task with an emotion induction block and we measured the amplitude of the N2, an event-related potential associated with inhibitory control, as it varied with block and with age. Furthermore, we estimated activation for a ventral prefrontal region of interest (ROI; suggestive of orbital frontal, ventromedial prefrontal, or rostral anterior cingulate activation) and a dorsomedial prefrontal ROI (suggestive of dorsal anterior cingulate activation) frequently modeled as cortical generators underlying the N2. Results revealed a marginal decrease in mediofrontal scalp activation, but a more pronounced decrease in activation of the ventromedial prefrontal ROI, with age. There were no age-related changes in dorsomedial prefrontal ROI activation. Lastly, as predicted, we found increased ventral prefrontal ROI activation during the negative emotion induction, possibly reflecting greater recruitment of frontocortical resources underlying emotion regulation, but developmental change in this activation was no different than for the other conditions. Thus, both self-regulation in general and emotion regulation in particular recruited less cortical activation with age, suggesting more efficient cortical mechanisms of response inhibition.
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DOI：
10.1073/pnas.96.14.8301
发表时间：
1999-07-06
影响因子：
11.1
作者：
Garavan, H;Ross, TJ;Stein, EA
通讯作者：
Stein, EA
影响因子：
3.4
作者：
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通讯作者：
Mattay, VS
影响因子：
2.5
作者：
Donkers, FCL;van Boxtel, GJM
通讯作者：
van Boxtel, GJM
影响因子：
4.7
作者：
Bokura, H;Yamaguchi, S;Kobayashi, S
通讯作者：
Kobayashi, S
影响因子：
5.7
作者：
Booth, JR;Burman, DD;Mesulam, MM
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Mesulam, MM