Extracellular Vesicles and Bone-Associated Cancer.
Extracellular Vesicles and Bone-Associated Cancer.
复制标题
细胞外囊泡与骨相关癌症
DOI：
10.1007/s11914-021-00668-w
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发表时间：
2021-06
影响因子：
4.3
通讯作者：
Keller ET
中科院分区：
文献类型：
--
作者：
Dai J;Shupp AB;Bussard KM;Keller ET
在这篇综述中，我们描述了细胞外囊泡（EV）的生物学以及它们如何导致骨相关癌症。肿瘤和骨之间的串扰已被证明促进肿瘤和转移进展。除了直接的细胞与细胞接触和可溶性因子，如细胞因子，EV介导肿瘤和骨之间的串扰。EV由不同大小范围、形成机制和内容物的膜描绘囊泡的异质组组成。这些包括凋亡小体、微泡、大癌小体和外来体。已显示源自原发性肿瘤的EV改变骨重塑并形成有利于骨转移发展的转移前小生境。类似地，来自骨髓基质细胞的EV已显示出促进肿瘤进展。此外，EV由于其低免疫原性和靶向特异性而可以充当治疗递送载体。EV在细胞间通信中起着关键作用。基于形成机制的大小，存在多种类别的EV。除了在病理生理学中的作用之外，EV还可以用作治疗递送载体。
In this review, we describe the biology of extracellular vesicles (EV) and how they contribute to bone-associated cancers. Crosstalk between tumor and bone have been demonstrated to promote tumor and metastatic progression. In addition to direct cell to cell contact and soluble factors, such as cytokines, EVs mediate crosstalk between tumor and bone. EVs are composed of a heterogenous group of membrane-delineated vesicles of varying size range, mechanisms of formation and content. These include apoptotic bodies, microvesicles, large oncosomes and exosomes. EVs derived from primary tumors have been shown to alter bone remodeling and create formation of a pre-metastatic niche that favors development of bone metastasis. Similarly, EVs from marrow stromal cells have been shown to promote tumor progression. Additionally, EVs can act as therapeutic delivery vehicles due to their low immunogenicity and targeting specificity. EVs play critical roles in intercellular communication. Multiple classes of EVs exist based on size on mechanism of formation. In addition to a role in pathophysiology, EVs can be exploited as therapeutic delivery vehicles.
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DOI：
10.1016/j.apsb.2016.02.001
发表时间：
2016-07
期刊：
Acta pharmaceutica Sinica. B
影响因子：
--
作者：
Ha D;Yang N;Nadithe V
通讯作者：
Nadithe V
影响因子：
7.3
作者：
French KC;Antonyak MA;Cerione RA
通讯作者：
Cerione RA
影响因子：
6.2
作者：
Loftus, Alexander;Cappariello, Alfredo;Rucci, Nadia
通讯作者：
Rucci, Nadia
影响因子：
5.1
作者：
Aryani A;Denecke B
通讯作者：
Denecke B
影响因子：
5.4
作者：
Antimisiaris SG;Mourtas S;Marazioti A
通讯作者：
Marazioti A