No Effect of Isolated Anthocyanins from Bilberry Fruit and Black Rice on LDL Cholesterol or other Biomarkers of Cardiovascular Disease in Adults with Elevated Cholesterol: A Randomized, Placebo-Controlled, Cross-Over Trial.
No Effect of Isolated Anthocyanins from Bilberry Fruit and Black Rice on LDL Cholesterol or other Biomarkers of Cardiovascular Disease in Adults with Elevated Cholesterol: A Randomized, Placebo-Controlled, Cross-Over Trial.
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DOI：
10.1002/mnfr.202101157
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发表时间：
2022-11
影响因子：
5.2
通讯作者：
中科院分区：
文献类型：
--
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据报道，浆果、浆果提取物和纯化花青素的一些饮食干预可以有益地改变高脂血症参与者的脂蛋白谱。人类饮食中的主要花青素是花青素和飞鸽苷的糖苷，其结构会影响吸收和生物活性。本研究的目的是确定两种主要类型的花青素对高脂血症患者低密度脂蛋白胆固醇和其他心血管疾病（CVD）风险的心脏代谢标志物的影响。52名高脂血症患者完成了这项随机、安慰剂对照、双盲、三臂交叉试验。参与者每天服用一次含有320毫克花青素（越橘三羟基型或黑米二羟基型）或安慰剂的胶囊，持续28天。在干预前后测量心血管疾病风险的生物标志物。与安慰剂相比，花青素治疗没有显著（p < 0.05）改变循环脂蛋白水平(总/高密度脂蛋白(HDL) /低密度脂蛋白（LDL) -胆固醇、甘油三酯、载脂蛋白B (ApoB)）、血糖控制生物标志物（空腹血糖、果糖胺）、HDL功能生物标志物（ApoA1、HDL3、对氧磷酶- 1 （PON1）芳基酯酶和内酯酶活性）或血浆胆汁酸。这些数据并不支持经常食用花青素有利于血糖控制或脂蛋白谱或功能的观点。无效果观察可能是由于治疗时间相对较短。每天食用从黑米和越橘中分离的花青素28天不会影响脂蛋白代谢、脂蛋白质量或葡萄糖控制的生物标志物。
Some dietary interventions with berry fruits, berry fruit extracts, and purified anthocyanins have been reported to beneficially alter lipoprotein profiles in hyperlipidemic participants. The major anthocyanins in human diets are glycosides of cyanidin and delphinidin, and structure can influence both absorption and bioactivity. The aim of this study is to determine the effects of two major types of anthocyanins on low‐density lipoprotein cholesterol and other cardiometabolic markers for cardiovascular disease (CVD) risk in hyperlipidemic individuals. Fifty‐two hyperlipidemic participants complete this randomized, placebo‐controlled, double‐blind, three arm crossover trial. Participants ingest capsules containing 320 mg of anthocyanins (bilberry trihydroxy‐type or black rice dihydroxy‐type) or placebo once daily for 28 days. Biomarkers of CVD risk are measured before and after the intervention period. Compared to the placebo, neither anthocyanin treatment significantly (p < 0.05) changes circulating levels of lipoproteins (total‐/high‐density lipoprotein (HDL)‐/low‐density lipoprotein (LDL)‐cholesterol, triglycerides, Apolipoprotein B (ApoB)), biomarkers of glycemic control (fasting glucose, fructosamine), biomarkers of HDL function (ApoA1, HDL3, paraoxonase‐1 (PON1) arylesterase, and lactonase activities), or plasma bile acids. These data do not support the notion that regular consumption of anthocyanins beneficially affects glycemic control or lipoprotein profiles or functions. It is possible the no effect observation is due to the relatively short duration of treatments. Daily consumption for 28 days of isolated anthocyanins from black rice and bilberry does not affect biomarkers of lipoprotein metabolism, lipoprotein quality, or glucose control.
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通讯作者：
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