Chromophore concentrations, absorption and scattering properties of human skin in-vivo.
Chromophore concentrations, absorption and scattering properties of human skin in-vivo.
复制标题
DOI：
10.1364/oe.17.014599
复制
发表时间：
2009-08-17
期刊：
影响因子：
3.8
通讯作者：
Kollias N
中科院分区：
文献类型：
--
作者：
Tseng SH;Bargo P;Durkin A;Kollias N
人体皮肤的吸收和降低散射系数为美学和临床目的提供了非侵入性皮肤诊断的关键信息。迄今为止，很少有关于体内皮肤光学特性的报道。在此之前，我们报道了使用“改进的两层几何结构”的扩散探针在650 - 1000nm波长范围内对体内皮肤的吸收和散射特性。在本研究中，我们在500 ~ 1000nm范围内连续测定了皮肤光学性质的光谱。结果发现，由于问讯区的固有差异，18名受试者在600nm上下波长的吸收光谱计算出的氧血红蛋白、脱氧血红蛋白、黑色素等发色团的浓度存在差异。散射功率与散射体的平均大小有关，显示了皮肤光型、皮肤部位和波长之间的明显对比。我们还对前臂进行静脉闭塞，发现在600nm以上和600nm以下波长评估的氧和脱氧血红蛋白浓度是不同的。我们的研究结果表明，利用可见光和近红外光源的漫反射技术可以研究上真皮和下真皮的血流动力学和光学特性。
Absorption and reduced scattering coefficients of in-vivo human skin provide critical information on non-invasive skin diagnoses for aesthetic and clinical purposes. To date, very few in-vivo skin optical properties have been reported. Previously, we reported absorption and scattering properties of in-vivo skin in the wavelength range from 650 to 1000nm using the diffusing probe in the “modified two-layer geometry”. In this study, we determine the spectra of skin optical properties continuously in the range from 500 to 1000nm. It was found that the concentration of chromophores, such as oxy-hemoglobin, deoxy-hemoglobin, and melanin, calculated based on the absorption spectra of eighteen subjects at wavelengths above and below 600nm were distinct because of the inherent difference in the interrogation region. The scattering power, which is related to the average scatterer’s size, demonstrates a clear contrast between skin phototypes, skin sites, and wavelengths. We also applied venous occlusion on forearms and found that the concentrations of oxy- and deoxy-hemoglobin as assessed at wavelengths above and below 600nm were different. Our results suggest that diffuse reflectance techniques with the visible and near infrared light sources can be employed to investigate the hemodynamics and optical properties of upper dermis and lower dermis.
登录
查看更多内容
影响因子：
3.5
作者：
Cerussi, Albert;Shah, Natasha;Tromberg, Bruce J.
通讯作者：
Tromberg, Bruce J.
影响因子：
3.6
作者：
Tseng, SH;Hayakawa, C;Durkin, AJ
通讯作者：
Durkin, AJ
影响因子：
6.1
作者：
WANG, LH;JACQUES, SL;ZHENG, LQ
通讯作者：
ZHENG, LQ
DOI：
10.1016/s1056-8719(97)00053-1
发表时间：
1997-10-01
影响因子：
1.9
作者：
Reinoso, RF;Telfer, BA;Rowland, M
通讯作者：
Rowland, M
影响因子：
4.3
作者：
Wolf, U;Wolf, M;Gratton, E
通讯作者：
Gratton, E