Pheromone modulates two phenotypically plastic traits - adult reproduction and larval diapause - in the nematode Caenorhabditis elegans.
Pheromone modulates two phenotypically plastic traits - adult reproduction and larval diapause - in the nematode Caenorhabditis elegans.
复制标题
信息素在线虫秀丽隐杆线虫中调节两个表型塑性性状 - 成人繁殖和幼虫滞育。
DOI：
10.1186/s12862-017-1033-9
复制
发表时间：
2017-08-22
影响因子：
3.4
通讯作者：
Viney M
中科院分区：
文献类型：
--
作者：
Wharam B;Weldon L;Viney M
动物利用来自环境的信息来做出决定，最终使其适应性最大化。线虫C.线虫有一个信息素信号系统，迄今为止，主要被认为是蠕虫用来决定是否阻止它们作为幼虫的发育。最近的研究表明，这种信息素可以有其他的作用，在C。elegans生命周期在这里，我们展示了一个新的角色，为C。elegans信息素，表明它加速雌雄同体的繁殖率，我们称之为信息素依赖的生殖可塑性（PDRP）的现象。我们还发现，信息素加速幼虫的生长速度，但这取决于活的细菌食物来源，而PDRP没有。不同的C。秀丽线虫株都显示PDRP，尽管这些效应的大小在株之间不同，这类似于该信息素也诱导的被捕幼虫表型的多样性。使用选择实验，我们还表明，选择PDRP或幼虫逮捕影响的目标和非目标性状，这表明这两个信息素依赖的性状之间存在串扰。这些结果表明，C。线虫的信息素是一种信号，作用于生命周期的两个关键点，控制幼虫的不同命运，并影响雌雄同体成虫的繁殖。更广泛地说，这些结果表明，正确理解和解释生物信息素信号在C。线虫和其他线虫，需要考虑这些生物在其自然环境中的生活史生物学。
Animals use information from their environment to make decisions, ultimately to maximize their fitness. The nematode C. elegans has a pheromone signalling system, which hitherto has principally been thought to be used by worms in deciding whether or not to arrest their development as larvae. Recent studies have suggested that this pheromone can have other roles in the C. elegans life cycle. Here we demonstrate a new role for the C. elegans pheromone, showing that it accelerates hermaphrodites’ reproductive rate, a phenomenon which we call pheromone-dependent reproductive plasticity (PDRP). We also find that pheromone accelerates larval growth rates, but this depends on a live bacterial food source, while PDRP does not. Different C. elegans strains all show PDRP, though the magnitude of these effects differ among the strains, which is analogous to the diversity of arrested larval phenotypes that this pheromone also induces. Using a selection experiment we also show that selection for PDRP or for larval arrest affects both the target and the non-target trait, suggesting that there is cross-talk between these two pheromone-dependent traits. Together, these results show that C. elegans’ pheromone is a signal that acts at two key life cycle points, controlling alternative larval fates and affecting adult hermaphrodites’ reproduction. More broadly, these results suggest that to properly understand and interpret the biology of pheromone signalling in C. elegans and other nematodes, the life-history biology of these organisms in their natural environment needs to be considered.
登录
查看更多内容
影响因子：
2.4
作者：
Viney M;Kikuchi T
通讯作者：
Kikuchi T
影响因子：
2.6
作者：
Diaz, S. Anaid;Viney, Mark
通讯作者：
Viney, Mark
DOI：
10.1093/gerona/glr143
发表时间：
2011-12-01
影响因子：
5.1
作者：
Anderson, Jennifer L.;Reynolds, Rose M.;Phillips, Patrick C.
通讯作者：
Phillips, Patrick C.
影响因子：
3.4
作者：
Diaz SA;Brunet V;Lloyd-Jones GC;Spinner W;Wharam B;Viney M
通讯作者：
Viney M
鉴定由胰岛素/IGF和类固醇激素信号通路调节的秀丽隐杆线虫中幼虫晚期发育检查点。
影响因子：
4.5
作者：
Schindler AJ;Baugh LR;Sherwood DR
通讯作者：
Sherwood DR