Performance on a modified signal detection task of attention is impaired in male and female rats following developmental exposure to the synthetic progestin, 17α-hydroxyprogesterone caproate.
Performance on a modified signal detection task of attention is impaired in male and female rats following developmental exposure to the synthetic progestin, 17α-hydroxyprogesterone caproate.
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雄性和雌性大鼠在发育过程中暴露于合成孕激素17α-羟孕酮己酸酯后，在修改的注意信号检测任务中的表现都受到了损害。
DOI：
10.1016/j.yhbeh.2021.105039
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发表时间：
2021-09
影响因子：
3.5
通讯作者：
Wagner CK
中科院分区：
文献类型：
--
作者：
Lolier M;Miller RO;Wood RI;Wagner CK
基于发育中的中皮质多巴胺通路对孕激素敏感的证据，在本研究中，我们检验了一种假说，即注意力是成功认知行为的基本组成部分，发育过程中暴露于合成孕激素17-α-羟孕酮己酸酯(17-OHPC)会扰乱注意力。为了评估注意障碍，采用了三种刺激方式的改良信号检测任务：复合刺激(光和音调)、单独的光和单独的音调，持续4个刺激时间(2，0.5，0.25，0.125 S)。成年大鼠被训练成，如果它们检测到刺激，就推一个杠杆，如果刺激没有出现，就推另一个杠杆。17-OHPC动物能够参与这项任务，与对照组相似的正确反应证明了这一点。然而，随着任务在较短持续时间内变得越来越困难，17-OHPC动物的遗漏明显多于对照组，这表明17-OHPC治疗可能会扰乱注意过程和/或延迟反应时间。这些发现补充了目前的文献，表明在发育过程中接触17-OHPC会导致成年后认知行为的缺陷。这些结果可能会向有早产史的孕妇提供与17-OHPC治疗相关的潜在风险，这些孕妇通常是这种治疗的接受者。
Based on evidence that the developing mesocortical dopamine pathway is sensitive to progestins, in the present study we tested the hypothesis that attention, a fundamental component of successful cognitive behavior, is disrupted by developmental exposure to the synthetic progestin, 17-α-hydroxyprogesterone caproate (17-OHPC). To assess attentional impairments, a modified signal detection task was utilized with three stimulus modalities: compound (light and tone), light alone, and tone alone, for four stimulus durations (2, 0.5, 0.25, 0.125 s). Adult rats were trained to push one lever if they detected the stimulus, and another lever if the stimulus was not presented. 17-OHPC animals were able to attend to the task, as evidenced by similar correct responses as controls. However, as the task became increasingly difficult at shorter durations, 17-OHPC animals made significantly more omissions compared to controls, suggesting that 17-OHPC treatment may disrupt attentional processes and/or delay response time. These findings add to the current body of literature demonstrating that exposure to 17-OHPC during development produces deficits in cognitive behavior in adulthood. These results may inform potential risks associated with 17-OHPC treatment in pregnant women with a history of preterm delivery who are commonly recipients of such treatment.
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影响因子：
3.2
作者：
Serpa RO;Wagner CK;Wood RI
通讯作者：
Wood RI
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