Saikosaponin D Rescues Deficits in Sexual Behavior and Ameliorates Neurological Dysfunction in Mice Exposed to Chronic Mild Stress.
Saikosaponin D Rescues Deficits in Sexual Behavior and Ameliorates Neurological Dysfunction in Mice Exposed to Chronic Mild Stress.
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柴胡皂苷 D 可挽救慢性轻度压力小鼠的性行为缺陷并改善神经功能障碍
DOI：
10.3389/fphar.2021.625074
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发表时间：
2021
影响因子：
5.6
通讯作者：
Chen J
中科院分区：
文献类型：
--
作者：
Wang Z;Li J;Wu W;Qi T;Huang Z;Wang B;Li S;Li C;Ding J;Zeng Y;Huang P;Zhou Z;Huang Y;Huang J;Wang X;Huang Q;Zhang G;Qiu P;Chen J
慢性压力通常与性功能障碍（SD）有关，是抑郁症发病的主要危险因素。柴胡是一种具有调节情志和性功能的中药制剂。柴胡皂苷D（saikosaponin D，SSD）是柴胡的主要活性成分，临床前研究证实其具有抗抑郁作用。在此，我们试图研究SSD恢复慢性应激小鼠性功能的作用，并阐明可能导致这些作用的潜在脑机制。在慢性轻度应激（CMS）诱导过程中，连续3周灌胃SSD，观察其对CMS小鼠情绪和性行为的影响。推测内侧背侧杏仁核（MePD）参与CMS小鼠性功能障碍的表现。我们的研究结果表明，SSD不仅减轻CMS引起的抑郁样行为，但也挽救CMS引起的低性动机和性表现差。CMS破坏MePD中的星形胶质细胞并激活小胶质细胞。SSD治疗逆转了CMS小鼠MePD中神经胶质病理学的变化，并抑制了神经炎症和氧化应激。SSD给药也减轻了MePD中的神经元形态和功能缺陷。我们的研究结果提供了深入了解与性功能障碍相关的大脑中枢机制。这些发现加深了我们对SSD在应激和性障碍的精神药理学方面的理解，为其潜在的临床应用提供了理论基础。
Often associated with sexual dysfunction (SD), chronic stress is the main contributing risk factor for the pathogenesis of depression. Radix bupleuri had been widely used in traditional Chinese medicine formulation for the regulation of emotion and sexual activity. As the main active component of Radix bupleuri, saikosaponin D (SSD) has a demonstrated antidepressant effect in preclinical studies. Herein, we sought to investigate the effect of SSD to restore sexual functions in chronically stressed mice and elucidate the potential brain mechanisms that might underly these effects. SSD was gavage administered for three weeks during the induction of chronic mild stress (CMS), and its effects on emotional and sexual behaviors in CMS mice were observed. The medial posterodorsal amygdala (MePD) was speculated to be involved in the manifestation of sexual dysfunctions in CMS mice. Our results revealed that SSD not only alleviated CMS-induced depressive-like behaviors but also rescued CMS-induced low sexual motivation and poor sexual performance. CMS destroyed astrocytes and activated microglia in the MePD. SSD treatment reversed the changes in glial pathology and inhibited neuroinflammatory and oxidative stress in the MePD of CMS mice. The neuronal morphological and functional deficits in the MePD were also alleviated by SSD administration. Our results provide insights into the central mechanisms involving the brain associated with sexual dysfunction. These findings deepen our understanding of SSD in light of the psychopharmacology of stress and sexual disorders, providing a theoretical basis for its potential clinical application.
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影响因子：
2.9
作者：
Gronli, J;Murison, R;Ursin, R
通讯作者：
Ursin, R
DOI：
10.1111/jsm.12201
发表时间：
2014-01
期刊：
The journal of sexual medicine
影响因子：
--
作者：
Breyer BN;Cohen BE;Bertenthal D;Rosen RC;Neylan TC;Seal KH
通讯作者：
Seal KH
影响因子：
3.1
作者：
Kedo, Olga;Zilles, Karl;Amunts, Katrin
通讯作者：
Amunts, Katrin
影响因子：
1.7
作者：
Brotto, LA;Gorzalka, BB;LaMarre, AK
通讯作者：
LaMarre, AK
影响因子：
3.4
作者：
Bancila, M;Giuliano, F;Vergé, D
通讯作者：
Vergé, D