Common and distinct neural targets of treatment: changing brain function in substance addiction.
Common and distinct neural targets of treatment: changing brain function in substance addiction.
复制标题
治疗的常见和独特的神经靶标：物质成瘾中的大脑功能改变。
DOI：
10.1016/j.neubiorev.2013.10.002
复制
发表时间：
2013-12
影响因子：
8.2
通讯作者：
Goldstein, Rita Z.
中科院分区：
文献类型：
--
作者：
Konova, Anna B.;Moeller, Scott J.;Goldstein, Rita Z.
关键词：
Neuroimaging offers an opportunity to examine the neurobiological effects of therapeutic interventions for human drug addiction. Using activation likelihood estimation, the aim of the current meta-analysis was to quantitatively summarize functional neuroimaging studies of pharmacological and cognitive-based interventions for drug addiction, with an emphasis on their common and distinct neural targets. More exploratory analyses also contrasted subgroups of studies based on specific study and sample characteristics. The ventral striatum, a region implicated in reward, motivation, and craving, and the inferior frontal gyrus and orbitofrontal cortex, regions involved in inhibitory control goal-directed behavior, were identified as common targets of pharmacological and cognitive-based interventions; these regions were observed when the analysis was limited to only studies that used established or efficacious interventions, and across imaging paradigms and types of addictions. Consistent with theoretical models, cognitive-based interventions were additionally more likely to activate the anterior cingulate cortex, middle frontal gyrus, and precuneus, implicated in self-referential processing, cognitive control, and attention. These results suggest that therapeutic interventions for addiction may target the brain structures that are altered across addictions and identify potential neurobiological mechanisms by which the tandem use of pharmacological and cognitive-based interventions may yield synergistic or complementary effects. These findings could inform the selection of novel functional targets in future treatment development for this difficult-to-treat disorder.
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DOI：
10.1111/j.1749-6632.2011.06270.x
发表时间：
2011-01-01
期刊：
CRITICAL CONTRIBUTIONS OF THE ORBITOFRONTAL CORTEX TO BEHAVIOR
影响因子：
--
作者：
Balleine, Bernard W.;Leung, Beatrice K.;Ostlund, Sean B.
通讯作者：
Ostlund, Sean B.
影响因子：
5.2
作者：
Chen BT;Hopf FW;Bonci A
通讯作者：
Bonci A
影响因子：
10.6
作者：
Brewer, Judson A.;Worhunsky, Patrick D.;Carroll, Kathleen M.;Rounsaville, Bruce J.;Potenza, Marc N.
通讯作者：
Potenza, Marc N.
影响因子：
4.2
作者：
Anderson, Ann L.;Reid, Malcolm S.;Li, Shou-Hua;Holmes, Tyson;Shemanski, Lynn;Slee, April;Smith, Edwina V.;Kahn, Roberta;Chiang, Nora;Vocci, Frank;Ciraulo, Domenic;Dackis, Charles;Roache, John D.;Salloum, Ihsan M.;Somoza, Eugene;Urschel, Harold C., III;Elkashef, Ahmed M.
通讯作者：
Elkashef, Ahmed M.
影响因子：
3.1
作者：
Crunelle, Cleo L.;Veltman, Dick J.;Booij, Jan;van Emmerik-van Oortmerssen, Katelijne;van den Brink, Wim
通讯作者：
van den Brink, Wim