Whole-Brain Mapping of the Inputs and Outputs of the Medial Part of the Olfactory Tubercle.
Whole-Brain Mapping of the Inputs and Outputs of the Medial Part of the Olfactory Tubercle.
复制标题
嗅结节内侧部分输入和输出的全脑映射
DOI：
10.3389/fncir.2017.00052
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发表时间：
2017
影响因子：
3.5
通讯作者：
Xu F
中科院分区：
文献类型：
--
作者：
Zhang Z;Zhang H;Wen P;Zhu X;Wang L;Liu Q;Wang J;He X;Wang H;Xu F
嗅结节内侧部是位于奖赏系统和嗅觉系统交界处的脑结构。它与信息素奖赏、自然强化、成瘾等行为密切相关。然而，OT内侧部分的解剖回路结构仍不清楚。在本研究中，OT的内侧部分被发现与广泛的脑区的伪狂犬病病毒追踪工具的帮助下，高度连接。为了进一步研究特定神经元的详细连接，另一种追踪工具-狂犬病病毒用于D1 R-cre和D2 R-cre小鼠。OT内侧部的D1 R和D2 R神经元均优先受嗅区特别是梨状皮质的支配，且两者具有相似的直接输入模式。在腺相关病毒标记的帮助下，发现这两个神经元亚群主要与奖赏相关的脑区一起支配，向嗅觉区投射的轴突略少。因此，在OT的内侧部分的特定类型的神经元的全脑输入和输出电路结构进行了系统的研究，结果揭示了许多独特的连接功能。本研究为进一步研究OT内侧部的生理功能提供了新的思路。
The medial part of the olfactory tubercle (OT) is a brain structure located at the interface of the reward and olfactory system. It is closely related to pheromone-rewards, natural reinforcement, addiction and many other behaviors. However, the structure of the anatomic circuitry of the medial part of the OT is still unclear. In the present study, the medial part of the OT was found to be highly connected with a wide range of brain areas with the help of the pseudorabies virus tracing tool. In order to further investigate the detailed connections for specific neurons, another tracing tool – rabies virus was utilized for D1R-cre and D2R-cre mice. The D1R and D2R neurons in the medial part of the OT were both preferentially innervated by the olfactory areas, especially the piriform cortex, and both had similar direct input patterns. With the help of the adeno-associated virus labeling, it was found that the two subpopulations of neurons primarily innervate with the reward related brain regions, with slightly less axons projecting to the olfactory areas. Thus, the whole-brain input and output circuitry structures for specific types of neurons in the medial part of the OT were systematically investigated, and the results revealed many unique connecting features. This work could provide new insights for further study into the physiological functions of the medial part of the OT.
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影响因子：
2.5
作者：
HABERLY, LB;PRICE, JL
通讯作者：
PRICE, JL
DOI：
10.1523/jneurosci.0154-12.2012
发表时间：
2012-06-06
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Igarashi KM;Ieki N;An M;Yamaguchi Y;Nagayama S;Kobayakawa K;Kobayakawa R;Tanifuji M;Sakano H;Chen WR;Mori K
通讯作者：
Mori K
影响因子：
3.3
作者：
GROVES, PM;LINDER, JC;YOUNG, SJ
通讯作者：
YOUNG, SJ
影响因子：
2.5
作者：
MILLHOUSE, OE;HEIMER, L
通讯作者：
HEIMER, L
影响因子：
3.3
作者：
Adjei, S.;Wesson, D. W.
通讯作者：
Wesson, D. W.