Diurnal pattern of salivary cortisol and progression of aortic stiffness: Longitudinal study.
Diurnal pattern of salivary cortisol and progression of aortic stiffness: Longitudinal study.
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DOI：
10.1016/j.psyneuen.2021.105372
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发表时间：
2021-11
影响因子：
3.7
通讯作者：
Brunner EJ
中科院分区：
文献类型：
--
作者：
Ikeda A;Steptoe A;Shipley M;Abell J;Kumari M;Tanigawa T;Iso H;Wilkinson IB;McEniery CM;Singh-Manoux A;Kivimaki M;Brunner EJ
压力和心血管疾病的发展之间的正向直接关系已越来越被认识到。然而，下丘脑-垂体-肾上腺（HPA）失调和亚临床心血管疾病之间的联系还没有纵向研究。我们研究了昼夜唾液皮质醇作为应激水平的生物标志物与五年以上主动脉僵硬进展的关系。在白厅II前瞻性研究中，共有3281人（平均年龄65.5岁）在一个工作日提供了6份唾液样本。我们评估了昼夜唾液皮质醇使用白天斜率和睡前水平。在基线（2007-2009年）和5年后（2012-2013年）通过颈动脉-股动脉脉搏波速度（PWV）测量主动脉硬度。线性混合模型被用来估计昼夜唾液皮质醇与基线PWV和五年纵向变化的关联。基线时，昼夜唾液皮质醇与PWV无关。在女性而非男性中，基线时唾液皮质醇斜率较浅的1-SD与PWV的5年增加（β = 0.199; 95% CI = 0.040，0.358 m/s）和睡前皮质醇水平较高（β = 0.208，95% CI = 0.062，0.354 m/s）相关。用唾液皮质醇测量HPA轴的失调（斜率较浅，睡前水平较高）可预测女性主动脉僵硬的进展率。第一次纵向研究是为了检查HPA失调与主动脉僵硬度的关系。这项研究对与心血管疾病发展相关的压力相关生物学改变提供了一些见解。我们的研究结果表明，HPA失调对主动脉僵硬进展的影响可能是性别特异性的。
The positive direct relation between stress and the development of cardiovascular disease has increasingly been recognized. However, the link between hypothalamic-pituitary-adrenal (HPA) dysregulation and subclinical cardiovascular disease has not been studied longitudinally. We investigated the relation of diurnal salivary cortisol, as a biological marker of stress levels, with progression of aortic stiffness over five years. A total of 3281 people (mean age 65.5) in the Whitehall II prospective study provided six saliva samples on a single weekday. We assessed the diurnal salivary cortisol using the daytime slope and bedtime level. Aortic stiffness was measured by carotid-femoral pulse wave velocity (PWV) at baseline (2007–2009) and five years later (2012–2013). Linear mixed models were used to estimate the association of diurnal salivary cortisol with baseline PWV and five-year longitudinal changes. Diurnal salivary cortisol were not associated with PWV at baseline. Among women but not men, a 1-SD shallower salivary cortisol slope at baseline was associated with a five-year increase in PWV (β = 0.199; 95% CI = 0.040, 0.358 m/s) and higher bedtime cortisol level (β = 0.208, 95% CI = 0.062, 0.354 m/s). Dysregulation of the HPA axis measured using salivary cortisol (shallower slope, higher bedtime level) predicted the rate of progression of aortic stiffness among women. The first longitudinal study was conducted to examine the relation of HPA dysregulation with aortic stiffness. This study gives some insight into stress-related biological alterations linked to cardiovascular disease development. Our findings demonstrated that the effects of HPA dysregulation on the progression of aortic stiffness may be sex-specific.
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影响因子：
3.7
作者：
Liao J;Brunner EJ;Kumari M
通讯作者：
Kumari M
影响因子：
3.7
作者：
Hajat, Anjum;Diez-Roux, Ana V.;Wu, Meihua
通讯作者：
Wu, Meihua
影响因子：
4.9
作者：
Waddell, TK;Dart, AM;Kingwell, BA
通讯作者：
Kingwell, BA
昼夜皮质醇斜率以及心理和身体健康结果：系统评价和荟萃分析。
影响因子：
3.7
作者：
Adam EK;Quinn ME;Tavernier R;McQuillan MT;Dahlke KA;Gilbert KE
通讯作者：
Gilbert KE
影响因子：
3.5
作者：
Cifkova, Renata;Pitha, Jan;Kralikova, Eva
通讯作者：
Kralikova, Eva