Tubulin-dynein system in flagellar and ciliary movement.

Tubulin-dynein system in flagellar and ciliary movement.
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DOI:
10.2183/pjab.88.397
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发表时间:
2012
期刊:
Proceedings of the Japan Academy. Series B, Physical and biological sciences
影响因子:
--
通讯作者:
Baba SA
Baba SA
中科院分区:
其他
文献类型:
--
作者:
Mohri H;Inaba K;Ishijima S;Baba SA

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在过去的一个世纪里,真核生物的鞭毛和纤毛引起了许多研究人员的注意,因为它们是高度排列的细胞器,并且表现出复杂的弯曲运动。在鞭毛和纤毛中首次发现并描述了两种重要的细胞骨架和运动蛋白:微管蛋白和动力蛋白。这两种蛋白质的发现已经过去了半个世纪,对它们的分子结构及其在微管滑动机制中的作用,以及鞭毛和纤毛的结构、弯曲运动机制以及调控和信号转导等方面都积累了大量的信息。介绍了这一领域的历史背景和最新进展。
Eukaryotic flagella and cilia have attracted the attention of many researchers over the last century, since they are highly arranged organelles and show sophisticated bending movements. Two important cytoskeletal and motor proteins, tubulin and dynein, were first found and described in flagella and cilia. Half a century has passed since the discovery of these two proteins, and much information has been accumulated on their molecular structures and their roles in the mechanism of microtubule sliding, as well as on the architecture, the mechanism of bending movement and the regulation and signal transduction in flagella and cilia. Historical background and the recent advance in this field are described.
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