Photochemical Modification of Single Crystalline GaN Film Using n-Alkene with Different Carbon Chain Lengths as Biolinker.
Photochemical Modification of Single Crystalline GaN Film Using n-Alkene with Different Carbon Chain Lengths as Biolinker.
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不同碳链长度的正烯烃作为生物链接剂对单晶GaN薄膜进行光化学修饰
DOI：
10.1021/acs.langmuir.6b00837
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发表时间：
2016
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--
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氮化镓（GaN）薄膜作为一种潜在的生物传感材料受到了广泛的关注。为了构建GaN生物传感器，生物连接剂的相应固定是非常重要的，以使表面具有生物活性。本工作中，采用三氟乙酰胺保护的烯丙胺（TFAAA）和三氟乙酰胺保护的10-氨基癸-1-烯（TFAAD）两种不同碳链长度的正烯烃对单晶GaN薄膜进行光化学功能化。通过飞行时间二次离子质谱（ToF-SIMS）测量证实了TFAAA和TFAAD与GaN膜的成功连接。随着UV照射时间的增加，对应于接头分子的二次离子的强度最初增加，随后在两种情况下降低。基于西姆斯测量，TFAAA的最大覆盖率是在14 h的UV照射后实现的，而在TFAAD的情况下仅需要2 h就达到完全覆盖GaN表面的情况。这一发现得出结论，与TFAAA相比，TFAAD的反应速率显著更高。通过原子力显微镜（AFM）的测量表明，由TFAAA层的GaN膜的覆盖导致增加的表面粗糙度。对于原始的GaN薄膜来说，可以清楚地观察到原子台阶，一旦表面完全被TFAAA层覆盖，原子台阶就会消失。这样的TFAAA层将以均匀的表面形貌为特征，即使反应时间为24小时。与此相反，TFAAD在表面上显示出强烈的交联聚合，这通过光学显微镜证实。这些结果表明，TFAAA是一个更合适的候选人作为生物链接的背景下的GaN表面，由于其改善的可控性。
As a potential material for biosensing applications, gallium nitride (GaN) films have attracted remarkable attention. In order to construct GaN biosensors, a corresponding immobilization of biolinkers is of great importance in order to render a surface bioactive. In this work, two kinds ofn-alkenes with different carbon chain lengths, namely allylamine protected with trifluoroacetamide (TFAAA) and 10-aminodec-1-ene protected with trifluoroacetamide (TFAAD), were used to photochemically functionalize single crystalline GaN films. The successful linkage of both TFAAA and TFAAD to the GaN films is confirmed by time-of-flight secondary ion mass spectrometry (ToF-SIMS) measurement. With increased UV illumination time, the intensity of the secondary ions corresponding to the linker molecules initially increases and subsequently decreases in both cases. Based on the SIMS measurements, the maximum coverage of TFAAA is achieved after 14 h of UV illumination, while only 2 h is required in the case of TFAAD to reach the situation of a fully covered GaN surface. This finding leads to the conclusion that the reaction rate of TFAAD is significantly higher compared to TFAAA. Measurements by atomic force microscopy (AFM) indicate that the coverage of GaN films by a TFAAA layer leads to an increased surface roughness. The atomic terraces, which are clearly observable for the pristine GaN films, disappear once the surface is fully covered by a TFAAA layer. Such TFAAA layers will feature a homogeneous surface topography even for reaction times of 24 h. In contrast to this, TFAAD shows strong cross-polymerization on the surface, this is confirmed by optical microscopy. These results demonstrate that TFAAA is a more suitable candidate as biolinker in context of the GaN surfaces due to its improved controllability.
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影响因子：
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作者：
Poghossian, A;Cherstvy, A;Schöning, MJ
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