Inflammation and depression symptoms are most strongly associated for Black adults.
Inflammation and depression symptoms are most strongly associated for Black adults.
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DOI：
10.1016/j.bbih.2022.100552
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发表时间：
2022-12
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影响因子：
--
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中科院分区：
文献类型：
--
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尽管在美国，种族/族裔与抑郁症和其他衰老疾病的风险存在显着差异相关，但这些健康差异背后的过程仍然知之甚少。我们通过研究炎症活动、C 反应蛋白 (CRP) 和抑郁症状的强有力标志物的水平在不同种族/族裔群体中的差异来解决这个问题。此外，我们还测试了炎症与抑郁之间的关联在各组之间是否存在差异。数据来自芝加哥社区成人健康调查，这是一项流行病学调查，旨在检查影响健康和福祉的生物心理社会因素。参与者为 3105 名芝加哥社区成年人，其中 610 名提供了血液样本并被纳入分析。从血液样本中检测 C 反应蛋白，并使用流行病学研究中心抑郁量表的 11 项抑郁症症状进行评估。种族/民族是自我报告的，包括黑人、西班牙裔、白人和其他种族/族裔群体。结果显示，这些种族/族裔群体的 CRP 和抑郁水平存在差异。具体来说，与白人和其他种族/族裔的美国人相比，美国黑人的 CRP 水平更高。此外，美国黑人比西班牙裔美国人表现出更多的抑郁症状。最后，我们发现炎症水平与抑郁症状密切相关，但仅限于美国黑人，仅 CRP 就占该亚组抑郁症状差异的 8%。因此，这些数据指出了一个生物过程，可能有助于解释美国不同种族/族裔心理健康结果的差异。与此同时，需要进行更多研究来了解驱动这些影响的社会和结构因素。
Although race/ethnicity is associated with substantial differences in risk for depression and other diseases of aging in the United States, the processes underlying these health disparities remain poorly understood. We addressed this issue by examining how levels of a robust marker of inflammatory activity, C-reactive protein (CRP), and depression symptoms varied across racial/ethnic groups. Additionally, we tested whether the inflammation-depression association differed across groups. Data were drawn from the Chicago Community Adult Health Survey, an epidemiological survey examining biopsychosocial factors affecting health and well-being. Participants were 3105 Chicago community adults, of which 610 provided blood samples and were included in analyses. C-reactive protein was assayed from blood samples, and depression symptoms were assessed using the 11-item Center for Epidemiologic Studies-Depression scale. Race/ethnicity was self-reported and consisted of Black, Hispanic, White, and other racial/ethnic groups. Results revealed that these racial/ethnic groups differed in terms of both their CRP and depression levels. Specifically, Black Americans exhibited higher levels of CRP as compared to White and other race/ethnicity Americans. Moreover, Black Americans exhibited more depression symptoms than Hispanic Americans. Finally, we found that inflammatory levels were strongly related to depression symptoms but only for Black Americans, with CRP alone accounting for 8% of the variance in depression symptoms in this subgroup. These data thus point to a biological process that may help to explain disparities in mental health outcomes across race/ethnicity in the United States. At the same time, additional research is needed to understand the social and structural factors driving these effects.
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影响因子：
4.5
作者：
Nazmi A;Victora CG
通讯作者：
Victora CG
DOI：
10.1017/s1742058x11000087
发表时间：
2011
期刊：
Du Bois review : social science research on race
影响因子：
--
作者：
Sternthal MJ;Slopen N;Williams DR
通讯作者：
Williams DR
影响因子：
6.3
作者：
Farmer HR;Wray LA;Xian Y;Xu H;Pagidipati N;Peterson ED;Dupre ME
通讯作者：
Dupre ME
影响因子：
10.6
作者：
Dowlati, Yekta;Herrmann, Nathan;Lanctot, Krista L.
通讯作者：
Lanctot, Krista L.
影响因子：
15.1
作者：
Case, Stephanie M.;Stewart, Jesse C.
通讯作者：
Stewart, Jesse C.