Impairment of novelty-related theta oscillations and P3a in never medicated first-episode psychosis patients.
Impairment of novelty-related theta oscillations and P3a in never medicated first-episode psychosis patients.
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DOI：
10.1038/s41537-021-00146-3
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发表时间：
2021-02-26
影响因子：
5.4
通讯作者：
de la Fuente-Sandoval C
中科院分区：
文献类型：
--
作者：
Solís-Vivanco R;Mondragón-Maya A;Reyes-Madrigal F;de la Fuente-Sandoval C
我们探讨了首次精神病发作（FEP）的抗精神病患者听觉新奇性检测的神经生理活动。15名非情感性FEP患者和13名健康对照者在EEG采集的同时进行了主动非自愿注意任务。计算了功率、锁相和额顶叶连接的时频表示。同时提取P3a事件相关电位。与对照组相比，FEP组表现出由异常刺激引起的锁相和额顶叶连接减少。P3a振幅明显降低。此外，在FEP组中，theta连接减少与更严重的阴性症状相关。与新颖性相关的θ波活动减少（锁相和连通性），以及P3a的减少，可能代表了与额顶叶注意网络密切相关的大规模神经群同步失败，并且可能被探索为新发精神病患者疾病严重程度的潜在生物标志物，因为它与阴性症状相关。
We explored the neurophysiological activity underlying auditory novelty detection in antipsychotic-naive patients with a first episode of psychosis (FEP). Fifteen patients with a non-affective FEP and 13 healthy controls underwent an active involuntary attention task along with an EEG acquisition. Time-frequency representations of power, phase locking, and fronto-parietal connectivity were calculated. The P3a event-related potential was extracted as well. Compared to controls, the FEP group showed reduced theta phase-locking and fronto-parietal connectivity evoked by deviant stimuli. Also, the P3a amplitude was significantly reduced. Moreover, reduced theta connectivity was associated with more severe negative symptoms within the FEP group. Reduced activity (phase-locking and connectivity) of novelty-related theta oscillations, along with P3a reduction, may represent a failure to synchronize large-scale neural populations closely related to fronto-parietal attentional networks, and might be explored as a potential biomarker of disease severity in patients with emerging psychosis, given its association with negative symptoms.
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