Long-term changes in time spent walking and subsequent cognitive and structural brain changes in older adults.
Long-term changes in time spent walking and subsequent cognitive and structural brain changes in older adults.
复制标题
老年人步行时间的长期变化以及随后的认知和大脑结构变化。
DOI：
10.1016/j.neurobiolaging.2017.05.023
复制
发表时间：
2017-09
影响因子：
4.2
通讯作者：
Health, Aging and Body Composition Study
中科院分区：
文献类型：
--
作者：
Best JR;Rosano C;Aizenstein HJ;Tian Q;Boudreau RM;Ayonayon HN;Satterfield S;Simonsick EM;Studenski S;Yaffe K;Liu-Ambrose T;Health, Aging and Body Composition Study
以前的研究表明，更活跃的老年人有更好的认知和大脑健康基于各种结构神经成像措施。然而，长期保持身体活动对老年人认知和大脑结构未来变化的影响尚不清楚。参与者是141名最初功能良好的社区居住老年人（基线年龄为70-79岁; 60%女性; 42%黑人），研究时间为13年。从第1年到第10年，每年评估身体活动（自我报告的步行时间）。在10岁和13岁时进行磁共振成像和扩散张量。从第1年到第10年，步行时间平均每年减少8.4%。独立于初始行走时间、人口统计学和APOE e4状态，10年内行走时间的更好维持预测海马体积减少较少（p = .03），整体灰质平均扩散率和白色轴向扩散率增加较少（p < .01），以及一般认知能力的维持（p < .01）。认知能力的维持与白色物质轴向扩散率的较小增加相关（p <0.01）。基线和第10年的PA以及PA在5年内的变化对大脑结构和认知的未来变化预测性较低。因此，身体活动水平在较长时间的衰老过程中如何变化可能是认知和神经保护的重要因素。
Previous studies have shown that more active older adults have better cognition and brain health based on a variety of structural neuroimaging measures. Nevertheless, the effects of maintaining physical activity over an extended period of time on future changes in older adults’ cognition and brain structure are unknown. Participants were 141 initially well-functioning community-dwelling older adults (aged 70–79 years at baseline; 60% female; 42% black) studied over a 13-year period. Physical activity (self-reported time spent walking) was assessed annually from years 1 to 10. Magnetic resonance imaging with diffusion tensor was performed at years 10 and 13. Time spent walking decreased on average by 8.4% annually from year 1 to year 10. Independent of initial time spent walking, demographics, and APOE e4 status, better maintenance of time spent walking over the decade predicted less reduction in hippocampal volume (p = .03), smaller increases in global gray matter mean diffusivity and white matter axial diffusivity (p < .01), and maintenance of general cognitive performance (p < .01). Maintenance of cognitive performance was associated with smaller increases in white matter axial diffusivity (p < .01). PA at baseline and at year 10, as well as changes in PA over a five-year period were less predictive of future changes in brain structure and cognition. Thus, how physical activity levels change over longer periods of aging may be an important contributor to cognitive and neural protection.
登录
查看更多内容
影响因子：
3.5
作者：
Erickson, Kirk I.;Prakash, Ruchika S.;Voss, Michelle W.;Chaddock, Laura;Hu, Liang;Morris, Katherine S.;White, Siobhan M.;Wojcicki, Thomas R.;McAuley, Edward;Kramer, Arthur F.
通讯作者：
Kramer, Arthur F.
直接与自我报告措施评估成人体育锻炼的比较：系统评价。
DOI：
10.1186/1479-5868-5-56
发表时间：
2008-11-06
影响因子：
8.7
作者：
Prince, Stephanie A.;Adamo, Kristi B.;Hamel, Meghan E.;Hardt, Jill;Gorber, Sarah Connor;Tremblay, Mark
通讯作者：
Tremblay, Mark
影响因子：
2.3
作者：
Johnson-Kozlow, Marilyn;Rock, Cheryl L.;Pierce, John P.
通讯作者：
Pierce, John P.
影响因子：
3.7
作者：
Burzynska, Agnieszka Zofia;Chaddock-Heyman, Laura;Kramer, Arthur F.
通讯作者：
Kramer, Arthur F.
影响因子：
4.2
作者：
Erickson KI;Leckie RL;Weinstein AM
通讯作者：
Weinstein AM