Prevalence of viral respiratory tract infections in children with asthma.
Prevalence of viral respiratory tract infections in children with asthma.
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DOI：
10.1016/j.jaci.2006.08.041
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发表时间：
2007-03
期刊：
影响因子：
--
通讯作者：
Teague WG
中科院分区：
文献类型：
--
作者：
Khetsuriani N;Kazerouni NN;Erdman DD;Lu X;Redd SC;Anderson LJ;Teague WG
先前的研究支持病毒性呼吸道感染与哮喘恶化之间的密切联系。新发现的病毒对哮喘控制的影响尚不明确。我们试图通过一组常见和新发现的呼吸道病毒的PCR检测来确定呼吸道病毒对儿童哮喘加重的作用。对2 ~ 17岁哮喘加重患儿（病例65例）和控制良好的哮喘患儿（对照77例）的呼吸道标本进行鼻病毒、肠道病毒、呼吸道合胞病毒、人中肺病毒、冠状病毒229E和OC43、副流感病毒1 ~ 3、流感病毒、腺病毒和人bocavavirus的检测，检测频率与年龄和入组季节相匹配。呼吸道病毒感染与哮喘加重相关（病例组63.1% vs对照组23.4%；优势比为5.6；95% CI为2.7- 11.6）。鼻病毒是迄今为止最流行的病毒（在病例患者中占60%，在对照组中占18.2%），也是唯一与病情恶化显著相关的病毒（优势比为6.8；95% CI为3.2-14.5）。然而，在没有临床表现的病毒性呼吸道疾病的儿童中，病例组鼻病毒感染的患病率（29.2%）与对照组（23.4%,P < 0.05）相似。其他检测到的病毒包括人中肺病毒（急性哮喘患者4.6% vs对照组2.6%）、肠道病毒（4.6% vs 0%）、冠状病毒229E （0% vs 1.3%）和呼吸道合胞病毒（1.5% vs 0%）。症状性鼻病毒感染是儿童哮喘加重的重要因素。这些结果支持需要有效的治疗鼻病毒作为一种手段，以减少哮喘恶化。
Previous studies support a strong association between viral respiratory tract infections and asthma exacerbations. The effect of newly discovered viruses on asthma control is less well defined. We sought to determine the contribution of respiratory viruses to asthma exacerbations in children with a panel of PCR assays for common and newly discovered respiratory viruses. Respiratory specimens from children aged 2 to 17 years with asthma exacerbations (case patients, n = 65) and with well-controlled asthma (control subjects, n = 77), frequency matched by age and season of enrollment, were tested for rhinoviruses, enteroviruses, respiratory syncytial virus, human metapneumovirus, coronaviruses 229E and OC43, parainfluenza viruses 1 to 3, influenza viruses, adenoviruses, and human bocavirus. Infection with respiratory viruses was associated with asthma exacerbations (63.1% in case patients vs 23.4% in control subjects; odds ratio, 5.6; 95% CI, 2.7- 11.6). Rhinovirus was by far the most prevalent virus (60% among case patients vs 18.2% among control subjects) and the only virus significantly associated with exacerbations (odds ratio, 6.8; 95% CI, 3.2-14.5). However, in children without clinically manifested viral respiratory tract illness, the prevalence of rhinovirus infection was similar in case patients (29.2%) versus control subjects (23.4%, P > .05). Other viruses detected included human metapneumovirus (4.6% in patients with acute asthma vs 2.6% in control subjects), enteroviruses (4.6% vs 0%), coronavirus 229E (0% vs 1.3%), and respiratory syncytial virus (1.5% vs 0%). Symptomatic rhinovirus infections are an important contributor to asthma exacerbations in children. These results support the need for therapies effective against rhinovirus as a means to decrease asthma exacerbations.
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DOI：
10.1164/ajrccm.155.6.9196088
发表时间：
1997-06-01
影响因子：
24.7
作者：
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DOI：
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发表时间：
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