Body size throughout the life-course and incident benign prostatic hyperplasia-related outcomes and nocturia.
Body size throughout the life-course and incident benign prostatic hyperplasia-related outcomes and nocturia.
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DOI：
10.1186/s12894-021-00816-5
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发表时间：
2021-03-27
期刊：
影响因子：
2
通讯作者：
Sutcliffe S
中科院分区：
文献类型：
--
作者：
Khan S;Wolin KY;Pakpahan R;Grubb RL;Colditz GA;Ragard L;Mabie J;Breyer BN;Andriole GL;Sutcliffe S
现有的证据表明，体型与普遍的良性前列腺增生（BPH）相关的结果和前列腺增生之间存在关联。然而，在整个生命过程中的身体尺寸和BPH相关结果之间的关联的证据有限。我们的研究人群包括前列腺癌、肺癌、结直肠癌和卵巢癌筛查试验（PLCO）干预组中无前列腺癌、BPH相关结局或前列腺增生病史的男性（n = 4710）。早期（20岁）、中期（50岁）和晚期体型的相关性（年龄≥ 55岁，平均年龄60.7岁）和体重变化与BPH相关结局（包括自我报告的夜尿和医生诊断的前列腺增生、直肠指检估计的前列腺体积≥ 30 cc，和前列腺特异性抗原[PSA]浓度> 1.4 ng/mL）使用具有稳健方差估计的Poisson回归进行检查。晚年肥胖的男性报告肥胖的可能性高出25%（相对危险度（RR）：1.25，95%置信区间（CI）：1.11-1.40;连续BMI < 0.0001的p趋势），在晚年超重或肥胖的男性更有可能报告前列腺体积≥ 30 cc（RR超重：1.13，95% CI 1.07-1.21; RR肥胖：1.10，95% CI 1.02-1.19;连续BMI的p趋势= 0.017）。20岁和50岁的肥胖与前列腺体积≥ 30 cc和前列腺体积≥ 30 cc的相关性相似。考虑到身体大小的变化轨迹，20岁时体重正常的男性在晚年变得超重或肥胖，（RR正常至超重：1.09，95% CI 0.98-1.22; RR正常至肥胖：1.28，95% CI 1.10-1.47）和前列腺体积≥ 30 cc（RR正常至超重：1.12，95% CI 1.05-1.20）。很少有男性在生命早期就肥胖，无法研究生命早期体型的独立影响。晚年的体型改变了体力活动和肥胖之间的联系。我们发现，晚年的身体大小，独立于早期的身体大小，与不良的BPH结果相关，这表明即使在晚年，减少身体大小的干预措施也可能减少BPH相关结果和肥胖的负担。在线版本包含补充材料，可通过10.1186/s12894-021-00816-5获得。
Existing evidence suggests that there is an association between body size and prevalent Benign Prostatic Hyperplasia (BPH)-related outcomes and nocturia. However, there is limited evidence on the association between body size throughout the life-course and incident BPH-related outcomes. Our study population consisted of men without histories of prostate cancer, BPH-related outcomes, or nocturia in the intervention arm of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) (n = 4710). Associations for body size in early- (age 20), mid- (age 50) and late-life (age ≥ 55, mean age 60.7 years) and weight change with incident BPH-related outcomes (including self-reported nocturia and physician diagnosis of BPH, digital rectal examination-estimated prostate volume ≥ 30 cc, and prostate-specific antigen [PSA] concentration > 1.4 ng/mL) were examined using Poisson regression with robust variance estimation. Men who were obese in late-life were 25% more likely to report nocturia (Relative Risk (RR): 1.25, 95% Confidence Interval (CI): 1.11–1.40; p-trendfor continuous BMI < 0.0001) and men who were either overweight or obese in late-life were more likely to report a prostate volume ≥ 30 cc (RRoverweight: 1.13, 95% CI 1.07–1.21; RRobese: 1.10, 95% CI 1.02–1.19; p-trendfor continuous BMI = 0.017) as compared to normal weight men. Obesity at ages 20 and 50 was similarly associated with both nocturia and prostate volume ≥ 30 cc. Considering trajectories of body size, men who were normal weight at age 20 and became overweight or obese by later-life had increased risks of nocturia (RRnormal to overweight: 1.09, 95% CI 0.98–1.22; RRnormal to obese: 1.28, 95% CI 1.10–1.47) and a prostate volume ≥ 30 cc (RRnormal to overweight: 1.12, 95% CI 1.05–1.20). Too few men were obese early in life to examine the independent effect of early-life body size. Later-life body size modified the association between physical activity and nocturia. We found that later-life body size, independent of early-life body size, was associated with adverse BPH outcomes, suggesting that interventions to reduce body size even late in life can potentially reduce the burden of BPH-related outcomes and nocturia. The online version contains supplementary material available at 10.1186/s12894-021-00816-5.
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影响因子：
23.4
作者：
Parsons, J. Kellogg;Schenk, Jeannette M.;Arnold, Kathryn B.;Messer, Karen;Till, Cathee;Thompson, Ian M.;Kristal, Alan R.
通讯作者：
Kristal, Alan R.
影响因子：
5
作者：
GIOVANNUCCI, E;RIMM, EB;WILLETT, WC
通讯作者：
WILLETT, WC
影响因子：
23.4
作者：
Parsons, J. Kellogg;Messer, Karen;Marshall, Lynn M.
通讯作者：
Marshall, Lynn M.
影响因子：
2.1
作者：
Girman, CJ;Jacobsen, SJ;Lieber, MM
通讯作者：
Lieber, MM
影响因子：
2.1
作者：
Gupta, Amit;Gupta, Sachin;Roehrborn, Claus G.
通讯作者：
Roehrborn, Claus G.