Medial prefrontal cortex and anteromedial thalamus interaction regulates goal-directed behavior and dopaminergic neuron activity.
Medial prefrontal cortex and anteromedial thalamus interaction regulates goal-directed behavior and dopaminergic neuron activity.
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DOI：
10.1038/s41467-022-28892-7
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发表时间：
2022-03-16
影响因子：
16.6
通讯作者：
Ikemoto S
中科院分区：
文献类型：
--
作者：
Yang C;Hu Y;Talishinsky AD;Potter CT;Calva CB;Ramsey LA;Kesner AJ;Don RF;Junn S;Tan A;Pierce AF;Nicolas C;Arima Y;Lee SC;Su C;Coudriet JM;Mejia-Aponte CA;Wang DV;Lu H;Yang Y;Ikemoto S
前额叶皮层与目标导向行为有关。在这里，我们调查的PFC电路调节动机，强化，以及它与多巴胺神经元活动的关系。fMRI显示，刺激小鼠内侧PFC（mPFC）神经元激活了许多下游区域。轴突终末刺激下游区域的mPFC神经元，包括丘脑前内侧核（AM），增强行为和激活中脑多巴胺能神经元。刺激投射到mPFC的AM神经元也能增强行为和激活多巴胺神经元，mPFC和AM表现出正反馈环结构。我们还发现，使用功能磁共振成像在观看强化视频剪辑的人类参与者中，存在相互的兴奋性功能连接，以及两个区域的共同激活。我们的研究结果表明，这个皮质丘脑回路调节动机，强化和多巴胺能神经元的活动。前额叶皮层与目标导向行为有关。在这里，作者表明，内侧前额叶皮层通过与前内侧丘脑的反馈回路激活目标导向的动机和多巴胺神经元。
The prefrontal cortex is involved in goal-directed behavior. Here, we investigate circuits of the PFC regulating motivation, reinforcement, and its relationship to dopamine neuron activity. Stimulation of medial PFC (mPFC) neurons in mice activated many downstream regions, as shown by fMRI. Axonal terminal stimulation of mPFC neurons in downstream regions, including the anteromedial thalamic nucleus (AM), reinforced behavior and activated midbrain dopaminergic neurons. The stimulation of AM neurons projecting to the mPFC also reinforced behavior and activated dopamine neurons, and mPFC and AM showed a positive-feedback loop organization. We also found using fMRI in human participants watching reinforcing video clips that there is reciprocal excitatory functional connectivity, as well as co-activation of the two regions. Our results suggest that this cortico-thalamic loop regulates motivation, reinforcement, and dopaminergic neuron activity. The prefrontal cortex is involved in goal-directed behaviour. Here the authors show that medial prefrontal cortex activates goal-directed motivation and dopamine neurons via a feedback loop with the anteromedial thalamus.
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影响因子：
3.6
作者：
FERRER, JMR;SANGUINETTI, AM;MORA, F
通讯作者：
MORA, F
DOI：
10.1098/rstb.1996.0125
发表时间：
1996-10-29
影响因子：
6.3
作者：
Damasio, AR
通讯作者：
Damasio, AR
影响因子：
2.7
作者：
CORBETT, D
通讯作者：
CORBETT, D
影响因子：
5.9
作者：
Cover CG;Kesner AJ;Ukani S;Stein EA;Ikemoto S;Yang Y;Lu H
通讯作者：
Lu H
影响因子：
16.2
作者：
Britt JP;Benaliouad F;McDevitt RA;Stuber GD;Wise RA;Bonci A
通讯作者：
Bonci A