The development of a Biobank of cancer tissue samples from World Trade Center responders.
The development of a Biobank of cancer tissue samples from World Trade Center responders.
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DOI：
10.1186/s12967-018-1661-x
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发表时间：
2018-10-11
影响因子：
7.4
通讯作者：
Taioli E
中科院分区：
文献类型：
--
作者：
Lieberman-Cribbin W;Tuminello S;Gillezeau C;van Gerwen M;Brody R;Donovan M;Taioli E
世贸中心（WTC）的救援人员暴露在粉尘、烟雾、化学物质和致癌物的混合物中。对这一人群癌症发病率的研究表明，与普通人群相比，这一人群患癌症的风险更高。有必要用癌症组织库补充目前的癌症流行病学随访，以便更好地阐明每种癌症与过去的WTC暴露之间的可能联系。这项工作描述了WTC新诊断癌症的组织库系统的实现，重点是促进对这些肿瘤生物学的理解。这将最终影响治疗方式，以及这些患者成功和生存的可能性。参与世贸中心现场救援、恢复和清理工作的世贸中心急救人员（作为雇员或志愿者）已在西奈山参加世贸中心健康计划。通过与纽约州、新泽西州、宾夕法尼亚州和康涅狄格州癌症登记处的联系确定和验证的癌症应答者有资格参与该生物库。通过信件、电话和电子邮件联系潜在的参与者，解释研究、同意过程，并获得他们进行癌症手术的地点。联系病理部门鉴定并索取组织样本。已经联系了西奈山数据中心确认的所有866例实体癌病例，并请求同意从其癌症中提取和储存组织样本。然后联系医院和医生办公室，为每位患者定位和确定正确的组织块。这些病例主要由2002年至2015年手术患者的档案石蜡块组成。在撰写论文时，生物样本库中储存了280个癌症样本。迄今为止，世贸中心响应者的癌症组织生物库已储存了280个标本。该组织库为科学界提供了一个重要的资源，可以对环境暴露和癌症病因学、癌症结局以及WTC应答者独特人群的基因-环境相互作用进行高影响研究。
World Trade Center (WTC) responders were exposed to mixture of dust, smoke, chemicals and carcinogens. Studies of cancer incidence in this population have reported elevated risks of cancer compared to the general population. There is a need to supplement current epidemiologic cancer follow-up with a cancer tissue bank in order to better elucidate a possible connection between each cancer and past WTC exposure. This work describes the implementation of a tissue bank system for the WTC newly diagnosed cancers, focused on advancing the understanding of the biology of these tumors. This will ultimately impact the modalities of treatment, and the probability of success and survival of these patients. WTC Responders who participated (as employees or volunteers) in the rescue, recovery and cleanup efforts at the WTC sites have been enrolled at Mount Sinai in the World Trade Center Health Program. Responders with cancer identified and validated through linkages with New York, New Jersey, Pennsylvania, and Connecticut cancer registries were eligible to participate in this biobank. Potential participants were contacted through letters, phone calls, and emails to explain the research study, consent process, and to obtain the location where their cancer procedure was performed. Pathology departments were contacted to identify and request tissue samples. All the 866 solid cancer cases confirmed by the Data Center at Mount Sinai have been contacted and consent was requested for retrieval and storage of the tissue samples from their cancer. Hospitals and doctors’ offices were then contacted to locate and identify the correct tissue block for each patient. The majority of these cases consist of archival paraffin blocks from surgical patients treated from 2002 to 2015. At the time of manuscript writing, this resulted in 280 cancer samples stored in the biobank. A biobank of cancer tissue from WTC responders has been compiled with 280 specimens in storage to date. This tissue bank represents an important resource for the scientific community allowing for high impact studies on environmental exposures and cancer etiology, cancer outcome, and gene-environment interaction in the unique population of WTC responders.
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影响因子：
10.4
作者：
McGee JK;Chen LC;Cohen MD;Chee GR;Prophete CM;Haykal-Coates N;Wasson SJ;Conner TL;Costa DL;Gavett SH
通讯作者：
Gavett SH
影响因子：
10.4
作者：
Lioy PJ;Weisel CP;Millette JR;Eisenreich S;Vallero D;Offenberg J;Buckley B;Turpin B;Zhong M;Cohen MD;Prophete C;Yang I;Stiles R;Chee G;Johnson W;Porcja R;Alimokhtari S;Hale RC;Weschler C;Chen LC
通讯作者：
Chen LC
DOI：
10.1097/jom.0b013e3181ad49c8
发表时间：
2009-08-01
影响因子：
3.2
作者：
Moline, Jacqueline M.;Herbert, Robin;Savitz, David A.
通讯作者：
Savitz, David A.
影响因子：
1.6
作者：
Kokkat, Theresa J.;Patel, Miral S.;Baloch, Zubair W.
通讯作者：
Baloch, Zubair W.
影响因子：
10.4
作者：
Herbert, Robin;Moline, Jacqueline;Levin, Stephen M.
通讯作者：
Levin, Stephen M.