Amygdala or hippocampus damage only minimally impacts affective responding to threat.
Amygdala or hippocampus damage only minimally impacts affective responding to threat.
复制标题
DOI：
10.1037/bne0000491
复制
发表时间：
2022-03
影响因子：
1.9
通讯作者：
Bliss-Moreau E
中科院分区：
文献类型：
--
作者：
Charbonneau JA;Bennett JL;Bliss-Moreau E
几十年来对猕猴内侧颞叶结构损伤的行为影响的研究证明，这种损伤，特别是杏仁核的损伤，会导致动物对威胁反应迟钝，并具有高度社会性。这种表型是行为神经科学中最广为人知的现象之一，也就是我们所熟知的“Klüver-Bucy综合征”。继承了评估患有颞叶病变的猴子对威胁的低敏感度的传统，我们评估了杏仁核或海马区双侧鹅掌酸损伤的恒河猴以及程序匹配的对照动物对不熟悉的人类入侵者和不同复杂程度的威胁物体的呈现的反应。所有动物的行为都符合预期--它们对刺激表面上的威胁值做出了反应，因此它们对最强的刺激反应最快，对最弱的刺激反应最小。与早先的报告相反，病变状态并不影响多种依赖措施(显性行为、笼子位置等)的反应模式。唯一与对威胁的低敏感度一致的损伤引起的差异是，杏仁核损伤的猴子比对照动物更快地提取放置在爬行动物类物体附近的食物奖励。这些发现质疑了杏仁核损伤会导致情感行为发生强有力的、刻板印象的变化的假设。他们还强调了在使用非人类灵长类动物进行神经科学研究中复制的重要性。
Decades of research studying the behavioral effects of damage to structures in medial temporal lobe of rhesus monkeys have documented that such damage, particularly damage to the amygdala, causes animals to become hyporesponsive to threat and hyper-social. This phenotype, a subset of the behaviors known as “Klüver-Bucy Syndrome”, is one of the most well-known phenomena in behavioral neuroscience. Carrying on the tradition of evaluating hyposensitivity to threat in monkeys with temporal lobe lesions, we evaluated the responses of rhesus monkeys with bilateral ibotenic acid lesions of the amygdala or hippocampus and procedure-matched control animals to the presentation of an unfamiliar human intruder and threatening objects of varying complexity. All animals behaved as expected — calibrating their responses to the ostensible threat value of the stimuli such that they were most responsive to the most potent stimuli and least responsive to the least potent stimuli. Contrary to an earlier report, lesion status did not impact the pattern of responses across multiple dependent measures (overt behaviors, position in cage, etc.). The only lesion induced difference consistent with hyposensitivity to threat was that monkeys with amygdala lesions retrieved food rewards placed near reptile-like objects more rapidly than did control animals. These findings call into question the assumption that amygdala damage causes robust, stereotyped changes to affective behavior. They also highlight the importance of replication in neuroscientific studies using nonhuman primates.
登录
查看更多内容
影响因子：
1.9
作者：
Bliss-Moreau E;Bauman MD;Amaral DG
通讯作者：
Amaral DG
DOI：
10.1037/h0077848
发表时间：
1981-01-01
期刊：
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
--
作者：
AGGLETON, JP;PASSINGHAM, RE
通讯作者：
PASSINGHAM, RE
影响因子：
10.6
作者：
Amaral, DG
通讯作者：
Amaral, DG
影响因子：
56.9
作者：
KALIN, NH;SHELTON, SE
通讯作者：
SHELTON, SE
DOI：
10.1073/pnas.1604288113
发表时间：
2016-12-13
影响因子：
11.1
作者：
Chareyron, Loic J.;Amaral, David G.;Lavenex, Pierre
通讯作者：
Lavenex, Pierre