Neonatal amygdala lesions result in globally blunted affect in adult rhesus macaques.
Neonatal amygdala lesions result in globally blunted affect in adult rhesus macaques.
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DOI：
10.1037/a0025757
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发表时间：
2011-12
影响因子：
1.9
通讯作者：
Amaral DG
中科院分区：
文献类型：
--
作者：
Bliss-Moreau E;Bauman MD;Amaral DG
一个多世纪以来，杏仁核一直与情感和社会加工有关。杏仁核受损的动物改变了情感和社会行为模式，尽管这些行为变化的确切性质取决于许多因素，包括损伤技术、受试者在损伤时的年龄、饲养和居住环境。杏仁核损伤研究的解释由于情感和社会刺激(例如，与一贯具有攻击性的同种伴侣的社会互动)的潜在混淆性质而进一步复杂化。在这项研究中，我们评估了一组恒河猴对社会和情感唤起视频刺激的情感反应，这些猕猴在出生时就接受了双侧杏仁核损伤。这些刺激的产生是为了独立地改变它们的情感和社会内容。将杏仁核受损的动物的反应与一组年龄匹配的对照组和一组在出生时遭受双侧海马区损伤的动物进行了比较。与对照动物相比，杏仁核损伤的动物对积极和消极刺激的反应迟钝，与社会内容无关，但确实区分了社会内容的类别。综上所述，这些发现表明，早期杏仁核损伤永久性地损害了情感处理，同时保持了区分具有社会意义的背景的能力。
The amygdala has been implicated in affective and social processing for more than a century. Animals with damage to the amygdala have altered affective and social behavior patterns, though the precise nature of these behavioral changes depends on a number of factors including lesion technique, age of the subject at the time of lesion, rearing, and housing environments. Interpretations of amygdala lesion studies are further complicated by the potentially confounded nature of affective and social stimuli (e.g., social interactions with a conspecific partner that is consistently aggressive). In the present study, we evaluated affective responding to socially and emotionally evocative video stimuli in a group of rhesus macaques that received bilateral amygdala lesions as neonates. The stimuli were produced in order to vary independently in terms of their affective and social content. The responses of the amygdala-lesioned animals were compared to a group of age-matched controls and a group of animals that had sustained bilateral hippocampus damage as neonates. As compared to control animals, amygdala-lesioned animals had blunted responding to both positive and negative stimuli, regardless of social content, but did differentiate between categories of social content. Taken together, these findings suggest that early amygdala damage permanently compromises affective processing while leaving intact the ability to distinguish between socially meaningful contexts.
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DOI：
10.1016/s0065-2601(08)00404-8
发表时间：
2009-01-01
期刊：
ADVANCES IN EXPERIMENTAL SOCIAL PSYCHOLOGY, VOL 41
影响因子：
--
作者：
Barrett, Lisa Feldman;Bliss-Moreau, Eliza
通讯作者：
Bliss-Moreau, Eliza
DOI：
10.1111/j.1749-6632.2003.tb07122.x
发表时间：
2003-01-01
期刊：
AMYGDALA IN BRAIN FUNCTION: BACIC AND CLINICAL APPROACHES
影响因子：
--
作者：
Malkova, L;Barrow, KV;Gale, K
通讯作者：
Gale, K
DOI：
10.1037/h0077848
发表时间：
1981-01-01
期刊：
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
--
作者：
AGGLETON, JP;PASSINGHAM, RE
通讯作者：
PASSINGHAM, RE
影响因子：
4.2
作者：
Eisenberger, Naomi I.;Gable, Shelly L.;Lieberman, Matthew D.
通讯作者：
Lieberman, Matthew D.
影响因子：
1.9
作者：
Machado, Christopher J.;Emery, Nathan J.;Amaral, David G.
通讯作者：
Amaral, David G.