Chick Hippocampal Formation Displays Subdivision- and Layer-Selective Expression Patterns of Serotonin Receptor Subfamily Genes.
Chick Hippocampal Formation Displays Subdivision- and Layer-Selective Expression Patterns of Serotonin Receptor Subfamily Genes.
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DOI：
10.3389/fphys.2022.882633
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发表时间：
2022
影响因子：
4
通讯作者：
Yamaguchi, Shinji
中科院分区：
文献类型：
--
作者：
Fujita, Toshiyuki;Aoki, Naoya;Mori, Chihiro;Fujita, Eiko;Matsushima, Toshiya;Homma, Koichi J.;Yamaguchi, Shinji
海马形成（HF）在哺乳动物的认知和情绪处理中起着关键作用。在高频神经回路中，5-羟色胺受体（5-HTRs）调节认知和情绪相关功能。为了了解认知和情绪的神经基础的系统发育连续性，确定调节动物认知和情绪加工的神经回路是很重要的。在鸟类中，HF已被证明与认知功能和情感相关行为有关。然而，关于5-HTRs在鸟类大脑中的分布的细节非常少，而且5-HTRs可能参与认知功能和情绪相关行为，但人们对其知之甚少。先前我们发现5-HTR1B和5-HTR3A在鸡HF中表达。为了确定其他可能参与禽类HF认知和情感功能的5-HTRs，我们选择了5-HTR1D、5-HTR1E、5-HTR1F、5-HTR2B、5-HTR5A和5-HTR7的鸡同源基因，并对鸡端脑进行了原位杂交。我们发现5-HTR1D、5-HTR1E、5-HTR5A和5-HTR7在鸡HF中有表达，特别是5-HTR1D和5-HTR1E的表达表现出细分和分层选择性，表明5-HT的特征性调控参与了这些HF区域的认知功能和情绪相关行为。这些发现有助于了解血清素在禽类HF中的调节作用，以及鸟类和哺乳动物HF亚型之间的对应关系。
Hippocampal formation (HF) plays a key role in cognitive and emotional processing in mammals. In HF neural circuits, serotonin receptors (5-HTRs) modulate functions related to cognition and emotion. To understand the phylogenetic continuity of the neural basis for cognition and emotion, it is important to identify the neural circuits that regulate cognitive and emotional processing in animals. In birds, HF has been shown to be related to cognitive functions and emotion-related behaviors. However, details regarding the distribution of 5-HTRs in the avian brain are very sparse, and 5-HTRs, which are potentially involved in cognitive functions and emotion-related behaviors, are poorly understood. Previously, we showed that 5-HTR1B and 5-HTR3A were expressed in chick HF. To identify additional 5-HTRs that are potentially involved in cognitive and emotional functions in avian HF, we selected the chick orthologs of 5-HTR1D, 5-HTR1E, 5-HTR1F, 5-HTR2B, 5-HTR5A, and 5-HTR7 and performed in situ hybridization in the chick telencephalon. We found that 5-HTR1D, 5-HTR1E, 5-HTR5A, and 5-HTR7 were expressed in the chick HF, especially 5-HTR1D and 5-HTR1E, which showed subdivision- and layer-selective expression patterns, suggesting that the characteristic 5-HT regulation is involved in cognitive functions and emotion-related behaviors in these HF regions. These findings can facilitate the understanding of serotonin regulation in avian HF and the correspondence between the HF subdivisions of birds and mammals.
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影响因子：
2.9
作者：
Atoji, Yasuro;Wild, J. Martin
通讯作者：
Wild, J. Martin
影响因子：
4
作者：
Fujita T;Aoki N;Mori C;Fujita E;Matsushima T;Homma KJ;Yamaguchi S
通讯作者：
Yamaguchi S
影响因子：
16.2
作者：
Fanselow, Michael S.;Dong, Hong-Wei
通讯作者：
Dong, Hong-Wei
影响因子：
2.7
作者：
Gupta, Sandeep;Maurya, Reshma;Sen, Jonaki
通讯作者：
Sen, Jonaki
影响因子：
4.7
作者：
BRUINVELS, AT;LANDWEHRMEYER, B;PALACIOS, JM
通讯作者：
PALACIOS, JM