Preparation and characterization of new nano-composite scaffolds loaded with vascular stents.
Preparation and characterization of new nano-composite scaffolds loaded with vascular stents.
复制标题
装载血管支架的新型纳米复合支架的制备与表征
DOI：
10.3390/ijms13033366
复制
发表时间：
2012
影响因子：
5.6
通讯作者：
Ren T
中科院分区：
文献类型：
--
作者：
Xu H;Su J;Sun J;Ren T
本研究采用静电纺丝技术制备了聚乳酸-β-己内酯/胶原/纳米羟基磷灰石（PLCL/Col/nHA）复合材料血管支架，并通过扫描电镜和拉伸试验对支架的表面形貌和断裂强度进行了观察和测量。通过静电层层自组装技术对抗凝血表面进行改性，评价支架的抗凝血性能。此外，采用热成型-颗粒沥滤法制备了负载血管支架的聚乳酸-羟基乙酸共聚物/聚己内酯/纳米羟基磷灰石（PLGA/PCL/nHA）纳米复合支架，并对其基本性能和体内成骨性能进行了测试。结果表明，PLCL/Col/nHA支架和PLGA/PCL/nHA纳米复合支架具有良好的表面结构、力学性能和生物相容性，并能引导骨再生。为构建血管化组织工程骨修复骨缺损提供了新的途径。
In this study, vascular stents were fabricated from poly (lactide-ɛ-caprolactone)/collagen/nano-hydroxyapatite (PLCL/Col/nHA) by electrospinning, and the surface morphology and breaking strength were observed or measured through scanning electron microscopy and tensile tests. The anti-clotting properties of stents were evaluated for anticoagulation surfaces modified by the electrostatic layer-by-layer self-assembly technique. In addition, nano-composite scaffolds of poly (lactic-co-glycolic acid)/polycaprolactone/nano-hydroxyapatite (PLGA/PCL/nHA) loaded with the vascular stents were prepared by thermoforming-particle leaching and their basic performance and osteogenesis were tested in vitro and in vivo. The results show that the PLCL/Col/nHA stents and PLGA/PCL/nHA nano-composite scaffolds had good surface structures, mechanical properties, biocompatibility and could guide bone regeneration. These may provide a new way to build vascularized-tissue engineered bone to repair large bone defects in bone tissue engineering.
登录
查看更多内容
DOI：
10.1007/s10856-010-4048-y
发表时间：
2010-06-01
影响因子：
3.7
作者：
Nguyen Thi Hiep;Lee, Byong-Taek
通讯作者：
Lee, Byong-Taek
影响因子：
14
作者：
Du, Fengyi;Wang, Hao;Zhang, Yuanyuan
通讯作者：
Zhang, Yuanyuan
影响因子：
14
作者：
Kim, SS;Park, MS;Kim, BS
通讯作者：
Kim, BS
影响因子：
2.1
作者：
Gu, Shuying;Zhan, Hui;Zhou, Xinyu
通讯作者：
Zhou, Xinyu
影响因子：
9.7
作者：
Wang, J.;Yu, X.
通讯作者：
Yu, X.