Effectiveness of companion-intensive multi-aspect weight management in Chinese adults with obesity: a 6-month multicenter randomized clinical trial.
Effectiveness of companion-intensive multi-aspect weight management in Chinese adults with obesity: a 6-month multicenter randomized clinical trial.
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中国成人肥胖症患者强化多方面体重管理的有效性：一项为期 6 个月的多中心随机临床试验
DOI：
10.1186/s12986-020-00511-6
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发表时间：
2021-02-03
影响因子：
4.5
通讯作者：
Zhou H
中科院分区：
文献类型：
--
作者：
Jiang W;Huang S;Ma S;Gong Y;Fu Z;Zhou L;Hu W;Mao G;Ma Z;Yang L;Tang G;Sun X;Zhang P;Bai J;Chen L;Shi B;Ye X;Zhou H
背景肥胖是一种全球性的健康流行病，需要早期的生活方式干预。我们的主要目的是研究同伴密集多方面体重管理（CIMWM）在中国成年肥胖患者中的有效性。MethodsIn this 6-month，prospective，open-label，multi-center，randomized controlled clinical trial，我们招募了272名肥胖成年人，年龄在18-50岁，体重指数（BMI）≥ 28. 0 kg/m2，能够使用智能手机。CIMWM（n = 136）提供每日在线指导和每月面对面的指导，由医生，营养师和健康管理人员沿着，并在前3个月提供代餐。传统的多方面体重管理（TMWM，n = 136）提供每月面对面的指导，由相同的专家小组和相同的代餐CIMWM组，但需要受试者完成日常自我监测，而不是提供每日在线指导。由医生在基线、1、2、3和6个月时评估身体组成和代谢参数。主要结果是临床显着的体重减轻和变化的BMI和身体composition.ResultsParticipants在两组显示显着降低BMI，体脂量（BFM），内脏脂肪面积（VFA），和HOMA-IR（p< 0.05）。CIMWM在改善临床显著的体重减轻、BMI、总胆固醇（TC）、身体成分参数BFM和骨骼肌质量与内脏脂肪面积比（S/V）方面上级TMWM（p< 0.05）。非酒精性脂肪性肝病评分（NFS）与基线S/V呈负相关。在体重管理后，NFS在具有最高三分位数水平的个体中降低（p< 0.05）。尽管参与者在最后3个月转移到自我监测评估，但在BMI，BFM和TC持续降低方面的代谢记忆保留长达6个月。结论CIMWM策略在肥胖的中国成年人中被证明比TMWM在减肥方面更有效，并激励更大的坚持干预和生活方式重新编程。ChiCTR 1800017463，于2018年7月31日注册。 http://www.chictr.org.cn/showproj.aspx?项目=29649 .
BackgroundObesity is a globally increasing health epidemic requiring early lifestyle intervention. Our main objective was to examine the effectiveness of companion-intensive multi-aspect weight management (CIMWM) in Chinese adults with obesity.MethodsIn this 6-month, prospective, open-label, multicenter, randomized controlled clinical trial, we recruited 272 obese adults aged 18–50 years with a body mass index (BMI) ≥ 28.0 kg/m2and capable of using smartphones. CIMWM (n = 136) offered both daily online instructions and monthly face-to-face guidance by physicians, dietitians, and health managers along with the provision of meal replacements in the first 3 months. Traditional multi-aspect weight management (TMWM, n = 136) provided monthly face-to-face guidance by the same panel of professionals and the same meal replacements as CIMWM group, but required subjects to complete daily self-monitoring instead of offering daily online instructions. Body composition and metabolic parameters were assessed at baseline, 1, 2, 3, and 6 months by physicians. The primary outcomes were clinically-significant weight loss and changes in BMI and body composition.ResultsParticipants in both groups showed significantly reduced BMI, body fat mass (BFM), visceral fat area (VFA), and HOMA-IR (p< 0.05). CIMWM was shown to be superior to TMWM in the improvement of clinically-significant weight loss, BMI, total cholesterol (TC), the body composition parameters BFM and the skeletal muscle mass-to-visceral fat area ratio (S/V) (p< 0.05). The non-alcoholic fatty liver disease score (NFS) was negatively related to S/V at baseline. After weight management, NFS was lowered among individuals with levels in the highest tertile (p< 0.05). Metabolic memory in terms of the continuous reduction of BMI, BFM, and TC was retained up to 6 months in spite of participants transferring to self-monitoring assessment in the final 3 months.ConclusionsThe CIMWM strategy in obese Chinese adults is proved to be more effective than TMWM in weight loss, and motivates greater adherence to intervention and lifestyle reprogramming.Trial registrationChinese Clinical Trial Registry, ChiCTR1800017463, Registered July 31, 2018. http://www.chictr.org.cn/showproj.aspx?proj=29649 .
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DOI：
10.1002/oby.21536
发表时间：
2016-08
期刊：
Obesity (Silver Spring, Md.)
影响因子：
--
作者：
Ross KM;Wing RR
通讯作者：
Wing RR
影响因子：
5.9
作者：
Fukushima Y;Kurose S;Shinno H;Thi Thu HC;Takao N;Tsutsumi H;Hasegawa T;Nakajima T;Kimura Y
通讯作者：
Kimura Y
影响因子：
4.9
作者：
Kelly, T.;Yang, W.;He, J.
通讯作者：
He, J.
影响因子：
6.9
作者：
Vink, Roel G.;Roumans, Nadia J. T.;van Baak, Marleen A.
通讯作者：
van Baak, Marleen A.
影响因子：
29.4
作者：
Azzu, Vian;Vacca, Michele;Vidal-Puig, Antonio
通讯作者：
Vidal-Puig, Antonio