Effects of Body Weight Reduction on Serum Irisin and Metabolic Parameters in Obese Subjects.
Effects of Body Weight Reduction on Serum Irisin and Metabolic Parameters in Obese Subjects.
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DOI：
10.4093/dmj.2016.40.5.386
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发表时间：
2016-10
影响因子：
5.9
通讯作者：
Kimura Y
中科院分区：
文献类型：
--
作者：
Fukushima Y;Kurose S;Shinno H;Thi Thu HC;Takao N;Tsutsumi H;Hasegawa T;Nakajima T;Kimura Y
鸢尾素是一种参与脂质和葡萄糖代谢的肌因子。本研究的目的是探讨体重减轻对日本肥胖非糖尿病患者血清鸢尾素水平和身体指标的影响。研究对象为22例患者（男/女5/17，年龄46.1±16.0岁，体重指数（BMI） 36.9±5.0 kg/m2），均在我院完成6个月的减肥计划。该项目包括饮食、运动疗法和认知行为疗法。在干预前后测定血液参数、体成分、运动耐量、胰岛素抵抗稳态模型评估（HOMA-IR）和血清鸢尾素，并检验这些数据变化之间的关系。干预后，体重和身体质量指数显著下降。干预前鸢尾素与HOMA-IR呈显著正相关（r=0.434， P<0.05）。所有参与者的平均鸢尾素水平在干预后均无显著变化。然而，干预后鸢尾素增加的患者体脂、皮下脂肪面积、甘油三酯和空腹血糖的改善明显大于鸢尾素减少的患者。鸢尾素升高的患者干预后空腹胰岛素（9.7±4.8比16.4±8.2，P<0.05）和HOMA-IR（2.2±1.1比3.7±1.6，P<0.05）均明显低于鸢尾素降低的患者。体重减轻并没有改变鸢尾素的水平。然而，鸢尾素可能在脂肪和葡萄糖代谢以及胰岛素抵抗中发挥重要作用，体重减轻对鸢尾素动力学的影响可能是肥胖治疗的关键。
Irisin is a myokine implicated in lipid and glucose metabolism. The objective of this study is to examine the effect of a body weight reduction on the serum irisin level and physical indicators in obese Japanese patients without diabetes. The subjects were 22 patients (male/female, 5/17; age, 46.1±16.0 years; body mass index [BMI], 36.9±5.0 kg/m2) who completed a 6-month body weight reduction program at our clinic. The program included diet, exercise therapy and cognitive behavioral therapy. Blood parameters, body composition, exercise tolerance, homeostasis model assessment of insulin resistance (HOMA-IR), and serum irisin were determined before and after intervention, and relationships among changes in these data were examined. There were significant decreases in body weight and BMI after the intervention. Irisin before the intervention was significantly positively correlated with HOMA-IR (r=0.434, P<0.05). The mean irisin level showed no significant change after the intervention in all participants. However, improvements in % body fat, subcutaneous fat area, triglycerides, and fasting glucose were significantly greater in patients with an increase in irisin compared to those with a decrease in irisin after the intervention. Patients with an increase in irisin also had significantly lower fasting insulin (9.7±4.8 vs. 16.4±8.2, P<0.05) and HOMA-IR (2.2±1.1 vs. 3.7±1.6, P<0.05) after the intervention, compared to patients with a decrease in irisin. Body weight reduction did not alter irisin levels. However, irisin may play important roles in fat and glucose metabolism and insulin resistance, and the effects of body weight reduction on irisin kinetics may be a key for obesity treatment.
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影响因子：
2
作者：
Moon, Seong-Su
通讯作者：
Moon, Seong-Su
影响因子：
2.2
作者：
Fukushima, Yaeko;Kurose, Satoshi;Shinno, Hiromi;Cao Thi Thu, Ha;Tamanoi, Atsuko;Tsutsumi, Hiromi;Hasegawa, Takaaki;Nakajima, Toshiaki;Kimura, Yutaka
通讯作者：
Kimura, Yutaka
影响因子：
4.9
作者：
Besse-Patin, A.;Montastier, E.;Viguerie, N.
通讯作者：
Viguerie, N.
影响因子：
5.1
作者：
Choi, Yeon-Kyung;Kim, Mi-Kyung;Park, Keun-Gyu
通讯作者：
Park, Keun-Gyu
影响因子：
3.2
作者：
de la Iglesia, Rocio;Lopez-Legarrea, Patricia;Martinez, Jose A.
通讯作者：
Martinez, Jose A.