Association between Maternal Characteristics and Immune Factors TGF-β1, TGF-β2, and IgA in Colostrum: An Exploratory Study in Japan.

Association between Maternal Characteristics and Immune Factors TGF-β1, TGF-β2, and IgA in Colostrum: An Exploratory Study in Japan.
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母亲特征与初乳中免疫因子TGF-β1、TGF-β2和伊加的关系:日本的探索性研究。

DOI:
10.3390/nu14163255
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发表时间:
2022-08-09
期刊:
影响因子:
5.9
通讯作者:
Yoshida K
Yoshida K
中科院分区:
医学2区
文献类型:
--
作者:
Hirata N;Kiuchi M;Pak K;Fukuda R;Mochimaru N;Mitsui M;Yoshida K

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初乳是新生儿的第一道食物,它含有多种重要的免疫因子。母乳中免疫因子的浓度可能会根据母亲的特征而变化,如体重指数,收集日期和首次怀孕的年龄。在这项探索性研究中,我们调查了初乳中TGF-β1、TGF-β2和伊加之间的关系,很少研究影响母乳成分的因素,包括使用引产药物、初乳分泌、新生儿性别、乳房或乳头问题以及乳头护理。从42名母亲中收集母乳样本,并分析TGF-β1、TGF-β2和伊加。结果表明,胎次和分娩方式可能与初乳中免疫因子的浓度有关。然而,我们发现初乳中的免疫因子与使用引产药物、初乳分泌、新生儿性别、乳房或乳头问题以及乳头护理之间没有关联。这些发现对进一步分析母乳中免疫因子对儿童过敏预后的影响具有一定的意义。
Colostrum is the first food for newborns and it contains various crucial immune factors. The concentrations of immune factors in breast milk may change depending on maternal characteristics such as body mass index, collection day, and age at first pregnancy. In this exploratory study, we investigated the association between TGF-β1, TGF-β2, and IgA in colostrum and rarely studied factors that affect breast milk components, including the use of labor-inducing medication, colostrum secretion, sex of newborns, breast or nipple problems, and nipple care. Breast milk samples were collected from 42 mothers and analyzed for TGF-β1, TGF-β2, and IgA. The results suggest that parity and mode of delivery may be correlated with the concentrations of immune factors in colostrum. However, we found no association between the immune factors in colostrum and the use of labor-inducing medications, colostrum secretion, sex of newborns, breast or nipple problems, and nipple care. These findings have some implications for further analysis of the effects of immune factors in breast milk on the prognosis of allergies in children.
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