Nonlinear associations between computed tomography-measures of adiposity and long pentraxin-3 in the Multi-Ethnic Study of Atherosclerosis.
Nonlinear associations between computed tomography-measures of adiposity and long pentraxin-3 in the Multi-Ethnic Study of Atherosclerosis.
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DOI：
10.1002/osp4.708
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发表时间：
2024-02
影响因子：
2.2
通讯作者：
Diamond, Joshua
中科院分区：
文献类型：
--
作者：
Anderson, Michaela R.;Kim, John S.;Podolanczuk, Anna;Ding, Jingzhong;Al-Naamani, Nadine;Allison, Matthew;Christie, Jason;Diamond, Joshua
长戊烷素‐3 （PTX‐3）是一种与心血管疾病、肺损伤和死亡率相关的急性期蛋白。我们评估了计算机断层扫描（CT）测量脂肪组织和血浆PTX - 3水平之间的关系。我们对参加多中心多种族动脉粥样硬化研究的社区居住成年人进行了横断面分析，这些成年人接受了心脏或腹部CT检查，并有可用的PTX‐3测量。心包脂肪组织体积（PAT）、腹部内脏脂肪组织面积（VAT）、肝脏衰减和PTX‐3水平呈U形相关，极端肥胖与较高的PTX‐3水平相关。使用多变量调整分段回归模型，在低PAT的参与者中，PAT体积每增加1%，PTX - 3减少13.8%(95%置信区间[CI] - 21.6至- 6.0)；在PAT高的参与者中，PAT体积每增加1%，PTX‐3增加6.0% （95% CI - 0.4 ~ 12.5）。腹部VAT和肝脏衰减的结果相似。在一个社区居住的成年人队列中，我们证明了心包、腹部内脏和肝脏脂肪与PTX3水平之间的“U形”关联，这表明极度肥胖与更高的循环PTX3水平相关。需要进一步的工作来确定肥胖和PTX‐3之间的联系机制。我们证明了脂肪组织与长戊烷素- 3水平之间的非线性关联。这可能解释了先前评估这种关联的文献中不一致的发现。这种关联现在可以用来证明进一步的研究是否长戊烷素- 3可以介导肥胖与心血管、肺损伤或癌症之间的关联。
Long pentraxin‐3 (PTX‐3) is an acute phase protein associated with cardiovascular disease, lung injury, and mortality. We evaluated the association between computed tomography (CT)‐measurements of adipose tissue and plasma levels of PTX‐3. We performed a cross‐sectional analysis of community‐dwelling adults enrolled in the multi‐center Multiethnic Study of Atherosclerosis who underwent cardiac or abdominal CT and had available PTX‐3 measurements. There was a U‐shaped association between pericardial adipose tissue volume (PAT), abdominal visceral adipose tissue area (VAT), hepatic attenuation, and PTX‐3 levels, with extremes of adiposity associated with greater PTX‐3 levels. Using multivariable‐adjusted piecewise regression models, among participants with low PAT, every 1% increase in PAT volume was associated with a 13.8% decrease in PTX‐3 (95% confidence interval [CI] −21.6 to −6.0); among participants with high PAT, every 1% increase in PAT volume was associated with a 6.0% increase in PTX‐3 (95% CI −0.4 to 12.5). Results were similar for abdominal VAT and hepatic attenuation. In a cohort of community‐dwelling adults, we demonstrated a “U‐shaped” association between pericardial, abdominal visceral, and hepatic adiposity with PTX3 levels, suggesting that extreme adiposity is associated with greater circulating levels of PTX3. Further work is required to identify the mechanisms linking adiposity and PTX‐3. We demonstrated a non‐linear association between the adipose tissue and long pentraxin‐3 levels. This may explain the inconsistent findings in the prior literature evaluating this association. This association can now be used to justify additional investigations into whether long pentraxin‐3 could mediate the association between adiposity and cardiovascular, lung injury, or cancer.
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DOI：
10.1111/obr.12358
发表时间：
2016-03
期刊：
Obesity reviews : an official journal of the International Association for the Study of Obesity
影响因子：
--
作者：
Heymsfield SB;Peterson CM;Thomas DM;Heo M;Schuna JM Jr
通讯作者：
Schuna JM Jr
成人肺移植候选物中内脏脂肪组织与脆弱的非线性关系。
DOI：
10.1111/ajt.15525
发表时间：
2019-11
期刊：
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
影响因子：
--
作者：
Anderson MR;Kolaitis NA;Gao Y;Kukreja J;Greenland J;Hays S;Wolters P;Golden J;Diamond J;Palmer S;Arcasoy S;Udupa J;Christie JD;Lederer DJ;Singer JP
通讯作者：
Singer JP
影响因子：
15.3
作者：
Faria, G.;Goncalves, A.;Taveira-Gomes, A.
通讯作者：
Taveira-Gomes, A.
影响因子：
5
作者：
Boyce, Cody J.;Pickhardt, Perry J.;Hinshaw, J. Louis
通讯作者：
Hinshaw, J. Louis
影响因子：
6.9
作者：
Ding, Jingzhong;Kritchevsky, Stephen B.;Carr, J. Jeffrey
通讯作者：
Carr, J. Jeffrey