Thyroid function and non-alcoholic fatty liver disease in hyperthyroidism patients.
Thyroid function and non-alcoholic fatty liver disease in hyperthyroidism patients.
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甲亢患者甲状腺功能与非酒精性脂肪肝
DOI：
10.1186/s12902-021-00694-w
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发表时间：
2021-02-18
影响因子：
2.7
通讯作者：
Gao X
中科院分区：
文献类型：
--
作者：
Wang B;Wang B;Yang Y;Xu J;Hong M;Xia M;Li X;Gao X
背景虽然甲状腺功能已被证明与不同人群中的非酒精性脂肪性肝病（NAFLD）相关，但甲亢中NAFLD的患病率和特征尚未见报道。本研究旨在调查甲亢患者NAFLD的患病率以及甲状腺功能与NAFLD的关系。方法本横断面研究在中国复旦大学附属中山医院进行。 2014年至2015年连续纳入117例甲亢患者，检测甲状腺功能等临床特征，彩色多普勒超声检测肝脏脂肪含量，肝脏脂肪含量大于9.15%的患者定义为NAFLD。采用SPSS 13.0软件包进行统计分析。结果甲亢患者NAFLD患病率为11.97%。患有 NAFLD 的患者游离三碘甲状腺原氨酸（FT3）和游离甲状腺素（FT4）水平低于非 NAFLD 患者（P< 0.05）。调整年龄、性别、代谢参数和炎症因素后，较高的FT3与较低的肝脏脂肪含量相关(β = − 0.072，P= 0.009)，并降低NAFLD的比值比(OR = 0.267，95%CI 0.087–0.817，P= 0.021)。结论FT3水平为负值与该人群的肝脏脂肪含量有关。这些结果可能为甲状腺激素对肝脏脂肪含量和NAFLD的调节作用提供新的证据。
BackgroundAlthough thyroid function has been demonstrated to be associated with non-alcoholic fatty liver disease (NAFLD) in different population, the prevalence and features of NAFLD in hyperthyroidism have not been reported. The present study aims to investigate the prevalence of NAFLD and association of thyroid function and NAFLD in hyperthyroidism patients.MethodsThis cross-sectional study was performed in Zhongshan Hospital, Fudan University, China. A total 117 patients with hyperthyroidism were consecutively recruited from 2014 to 2015. Thyroid function and other clinical features were measured, liver fat content was measured by color Doppler ultrasonically, NAFLD was defined in patients with liver fat content more than 9.15%. Statistical analyses were performed with SPSS software package version 13.0.ResultsThe prevalence of NAFLD was 11.97% in hyperthyroidism. Patient with NAFLD had lower free triiodothyronine (FT3) and free thyroxine (FT4) levels than patients without NAFLD (P< 0.05). After adjusting for age, gender, metabolic parameters and inflammation factors, higher FT3 were associated with lower liver fat content (β = − 0.072,P= 0.009) and decreased odds ratio of NAFLD (OR = 0.267, 95%CI 0.087–0.817,P= 0.021).ConclusionsFT3 level was negatively associated with the liver fat content in this population. These results may provide new evidence in the role of thyroid hormone on the regulation of liver fat content and NAFLD.
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