Reparative and Maladaptive Inflammation in Tendon Healing.
Reparative and Maladaptive Inflammation in Tendon Healing.
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DOI:
10.3389/fbioe.2021.719047
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发表时间:
2021
影响因子:
5.7
通讯作者:
Huang AH
中科院分区:
文献类型:
--
作者:
Arvind V;Huang AH
Tendon injuries are common and debilitating, with non-regenerative healing often resulting in chronic disease. While there has been considerable progress in identifying the cellular and molecular regulators of tendon healing, the role of inflammation in tendon healing is less well understood. While inflammation underlies chronic tendinopathy, it also aids debris clearance and signals tissue repair. Here, we highlight recent findings in this area, focusing on the cells and cytokines involved in reparative inflammation. We also discuss findings from other model systems when research in tendon is minimal, and explore recent studies in the treatment of human tendinopathy to glean further insights into the immunobiology of tendon healing.
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