Reparative and Maladaptive Inflammation in Tendon Healing.

Reparative and Maladaptive Inflammation in Tendon Healing.
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DOI:
10.3389/fbioe.2021.719047
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发表时间:
2021
影响因子:
5.7
通讯作者:
Huang AH
Huang AH
中科院分区:
工程技术2区
文献类型:
--
作者:
Arvind V;Huang AH

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肌腱损伤是常见的,使人衰弱,不可再生愈合常常导致慢性疾病。虽然在确定肌腱愈合的细胞和分子调节因子方面已经取得了相当大的进展,但炎症在肌腱愈合中的作用还不太清楚。虽然炎症是慢性肌腱病的基础,但它也有助于清除碎片并发出组织修复的信号。在这里,我们重点介绍了这一领域的最新发现,重点是参与修复性炎症的细胞和细胞因子。我们还讨论了其他模型系统在肌腱研究较少时的发现,并探讨了人类肌腱病治疗的最新研究,以进一步了解肌腱愈合的免疫生物学。
Tendon injuries are common and debilitating, with non-regenerative healing often resulting in chronic disease. While there has been considerable progress in identifying the cellular and molecular regulators of tendon healing, the role of inflammation in tendon healing is less well understood. While inflammation underlies chronic tendinopathy, it also aids debris clearance and signals tissue repair. Here, we highlight recent findings in this area, focusing on the cells and cytokines involved in reparative inflammation. We also discuss findings from other model systems when research in tendon is minimal, and explore recent studies in the treatment of human tendinopathy to glean further insights into the immunobiology of tendon healing.
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