Fatty-acid amide hydrolase polymorphisms and post-traumatic stress disorder after penetrating brain injury.
Fatty-acid amide hydrolase polymorphisms and post-traumatic stress disorder after penetrating brain injury.
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DOI：
10.1038/tp.2012.1
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发表时间：
2012-01-31
影响因子：
6.8
通讯作者：
Grafman J
中科院分区：
文献类型：
--
作者：
Pardini M;Krueger F;Koenigs M;Raymont V;Hodgkinson C;Zoubak S;Goldman D;Grafman J
在过去的几年里，人们对创伤后应激障碍 (PTSD) 的临床认识有所提高，这是最令人丧失能力和最不为人所知的行为障碍之一。尽管对 PTSD 的生物学基础知之甚少，但脂肪酸酰胺水解酶 (FAAH) 活性与唤醒性和厌恶记忆消退有关，即 PTSD 的两个关键特征。在这项研究中，我们调查了 FAAH 基因多态性与 PTSD 发展和维持之间的关联。我们评估了一组遭受战斗相关穿透性脑外伤的男性越南战争退伍军人的 PTSD 频率，即在导致 PTSD 的事件性质方面相对同质的人群。我们发现，FAAH 的单核苷酸多态性 rs2295633 与腹内侧前额叶皮层无病变的受试者的 PTSD 诊断显着相关。此外，C等位基因的存在与更严重的创伤再经历和更多负面的童年经历相关。总之，我们的数据表明，FAAH 通过调节厌恶记忆在 PTSD 中发挥重要作用，并指出了这种情况的新治疗靶点和可能的风险标记。
The past few years have seen an increase in the clinical awareness of post-traumatic stress disorder (PTSD), one of the most disabling and least understood behavioral disorders. Although the biological bases of PTSD are poorly understood, fatty-acid amide hydrolase (FAAH) activity has been linked with arousability and aversive-memories extinction, that is, two key features of PTSD. In this study, we investigated the association between the FAAH genetic polymorphisms and PTSD development and maintenance. We assessed PTSD frequency in a group of male Vietnam war veterans who suffered combat-related penetrating traumatic brain injury, that is, a relatively homogeneous population regarding the nature of the events that led to PTSD. We showed that rs2295633, a single-nucleotide polymorphism of FAAH, was significantly associated with PTSD diagnosis in subjects without lesions in the ventromedial prefrontal cortex. Moreover, the presence of the C allele was associated with more severe re-experiencing of trauma and more negative reported childhood experiences. In conclusion, our data suggest that FAAH has an important role in PTSD through modulation of aversive memories and point to both a novel therapeutic target and a possible risk marker for this condition.
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影响因子：
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作者：
KESSLER, RC;SONNEGA, A;NELSON, CB
通讯作者：
NELSON, CB
影响因子：
9.9
作者：
Pardini, M.;Krueger, F.;Grafman, J.
通讯作者：
Grafman, J.
影响因子：
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作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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